QBI Neuroscience Seminar: 'Unusual trafficking Routes in Axonal Transport'

Event Details

Date:

Tuesday, 10 December 2019 - Tuesday, 10 December 2019

Time:

11:00 am - 12:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Queensland Brain Institute (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Professor Subhojit Roy
Departments of Pathology and Neurosciences
University of California, San Diego

Title: 'Unusual trafficking Routes in Axonal Transport'

Abstract: Due to their complex geometry and finite sites of bulk protein synthesis in the perikarya, neurons have evolved elaborate transport and trafficking machinery to deliver proteins into axons and dendrites. Knowledge into the biology of this process is critical to our understanding of neuronal form and function. Disrupted trafficking is also a feature of many neurodegenerative diseases, and trafficking-routes can often be harnessed for therapeutic manipulations - underscoring their relevance to health and disease. This talk will focus on the unusual modes of trafficking employed by cytosolic ('soluble') and cytoskeletal proteins that comprise the majority of transported material, yet are the least studied among all transport cargoes; sluggishly moving in a mysterious rate-class called slow axonal transport.