QBI Neuroscience Seminar : 'Molecular Mechanisms of Glutamate Receptor Trafficking'

Event Details

Date:

Wednesday, 25 September 2019 - Wednesday, 25 September 2019

Time:

11:00 am - 12:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Queensland Brain Institute (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Dr Victor Anggono
Queensland Brain Institute
University of Queensland

Title: MOLECULAR MECHANISMS OF GLUTAMATE RECEPTOR TRAFFICKING

Abstract: Neuronal communication at excitatory synapses relies on the release of glutamate from the presynaptic terminals and their subsequent binding to postsynaptic glutamate receptors. The number of glutamate receptors at the synapse is one of the major determinants of synaptic efficacy. Dynamic changes in synaptic strength, known as synaptic plasticity, are thought to underlie information coding and storage during learning and memory. Aberrant trafficking of glutamate receptors into and out of synapses usually leads to impairment in synaptic plasticity and deficits in learning and memory. More importantly, there are growing evidence that demonstrate a strong link between defective glutamatergic neurotransmission and cognitive decline associated with various neurodegenerative diseases and neuropsychiatric disorders. Here, I will present data and discuss our efforts in elucidating the molecular mechanisms that control the trafficking of two major glutamate receptors, namely AMPA- and NMDA-receptors, by intracellular glutamate receptor interacting proteins and post-translational modifications that occur on their carboxyl termini.