IMB Seminar Series - Professor Karla Neugebauer - RNA: Master or Servant?
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- RNA: Master or Servant?
RNA has sequence and structure that give it great versatility. It can expose side chains in single stranded regions for protein interaction or translation. It can hide in complicated stem loops. It can be catalytic. These are some of the properties that cause us to love RNA as a molecule. However well this is appreciated by the wider community of biologists, RNA is still viewed as a messenger racing barefoot between the realms of two great kings. Perhaps we have this unconscious bias about RNA, because these are the fairytales we grew up with. My lab studies RNA processing events localized on nascent RNA at sites of transcription (genes) as well as nuclear Cajal bodies, which are the assembly sites for RNA-protein complexes involved in splicing. Our findings lead us to ask: Is it possible that RNA has even greater capacity to organize cells than we have imagined already?
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