QBI Research Presentation: Peripheral immune modifications in Alzheimer’s disease - a focus on myeloid dendritic cells
Event Details
- Date:
- Wednesday, 24 June 2015 - Wednesday, 24 June 2015
- Time:
- 1:45 pm - 2:30 pm
- Room:
- QBI Level 7 Auditorium
- UQ Location:
- Queensland Brain Institute (St Lucia)
- URL:
- http://www.qbi.uq.edu.au/neuroscience-seminars
- Event category(s):
Event Contact
- Name:
- Ms Deirdre Wilson
- Phone:
- 66300
- Email:
- d.wilson5@uq.edu.au
- Org. Unit:
- Queensland Brain Institute
Event Description
- Full Description:
- Dr Paola Bossu
Laboratory of Experimental Neuro-psychobiology, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
Title: Peripheral immune modifications in Alzheimer’s disease: a focus on myeloid dendritic cells
Abstract:
Alzheimer’s disease (AD) is an incurable neurodegenerative disturbance leading to dementia and characterized by a neuroinflammatory component. Inflammation is a promising target for therapeutic improvement of the disease, nevertheless the exact immune mechanisms underlying neurodegeneration are still unclear.
Microglia, the resident immune cells of the brain are the main cellular players in AD neuroinflammatory response, but the contribution of peripheral immune mediators and blood-derived mononuclear cells are emerging as potential important events in AD pathophysiology. Dendritic cells (DCs) are major orchestrators of the immune and inflammatory response, and based on accumulating evidence, including GWAS studies that point to myeloid cells as key components of AD susceptibility and progression, it can be hypothesized that myeloid DCs are involved as mediators of the disease.
In this presentation, the evidence about modifications of human monocyte-derived DCs, either obtained from AD patients or in vitro cultured with AD-associated pathogenic factors, will be summarized. Further, the most recent data reporting changes in blood DCs and their overall relationship with disease outcome in AD patients will be also presented and discussed.
However, since the understanding of both peripheral and brain immune response mechanisms and their impact in modulating the disease proves arduous in AD patients owing to the difficulty to look at cellular and molecular pathways within the human brain, the best possible approach to explore AD-related peripheral immune modifications is to use in a comprehensive and coordinated manner both clinical and animal settings of the disease.
Overall, the reported findings argue for the involvement of DCs in AD, implicating that a better understanding of DCs impact on neurodegeneration would allow to uncover peripheral immune mechanisms of pathogenic relevance and to recognize potential predictive/prognostic biomarkers exploitable as broadly applicable tests, suitable to improve research and treatment prospects for patients suffering from this devastating brain disease.
Directions to UQ
- Google Map:
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- Directions:
- St Lucia Campus | Gatton campus.
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