High-frequency oscillations for the localisation of the epileptogenic tissue
Event Details
- Date:
- Tuesday, 25 June 2019 - Tuesday, 25 June 2019
- Time:
- 9:30 am - 10:30 am
- Room:
- Level 2 seminar room
- Location:
- Building 57, Centre for Advanced Imaging, St Lucia campus
- URL:
- https://cai.centre.uq.edu.au/event/session/1636
- Event category(s):
Event Contact
- Name:
- Miss Maria Moran
- Phone:
- 51785
- Email:
- m.moran3@uq.edu.au
- Org. Unit:
- Advanced Imaging
Event Description
- Full Description:
- Javier Urriola, Neuroimaging biomarkers in Epilepsy - Reutens Group, UQ Centre for Advanced Imaging, presents:
High-frequency oscillations for the localisation of the epileptogenic tissue
Electroencephalographic (EEG) transients such as epileptic spikes are imperfect markers for the localisation of the surgical target in patients with drug-resistant focal epilepsy, showing poor concordance between the brain regions generating spikes and the seizure-generating tissue. Recently, high-frequency oscillations (HFOs) have been demonstrated to be a more reliable marker in delineating spontaneous seizure-generating regions. In this seminar, I summarise the main findings of my PhD using HFOs for the non-invasive localisation of the epileptogenic tissue.
This project investigated the differences between the scalp electrical topological patterns and neural correlates of epileptic spikes with and without HFOs in pre-surgical epilepsy patients using simultaneous voltage-map EEG-fMRI. Additionally, the differences and similarities of the patient-specific scalp voltage patterns and their respective neural correlates in a group of healthy volunteers were explored.
The results revealed that (1) spikes with and without HFOs have different scalp-voltage distributions, (2) the haemodynamic response of the voltage-maps of spikes with and without HFOs have similar substrate and concordance for the localisation of the epileptogenic region and, (3) patients showed distinct fMRI activations and increased occurrence of the pathological voltage not seen in healthy individuals indicating the presence of pathological networks associated with the generation of spikes with HFOs.
*No RSVP is required and all guests are welcome to join us for morning tea following the seminar for discussions and networking.
Event Tools
Share This Event
Print
Email
Share
