Event Details

Date:
Wednesday, 26 June 2019 - Wednesday, 26 June 2019
Time:
11:00 am - 12:00 pm
Room:
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
URL:
http://www.qbi.uq.edu.au/neuroscience-seminars
Event category(s):

Event Contact

Name:
Ms Deirdre Wilson
Phone:
66300
Email:
d.wilson5@uq.edu.au
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Professor Helen Cooper
Queensland Brain Institute
University of Queensland

Title: 'Understanding the molecular origins of cortical malformations'

Abstract: The fidelity of neocortical development is dependent on the highly polarized morphology of the neuroepithelial progenitors (NEPs) - the neural stem cells that line the embryonic ventricles. During embryogenesis the neuroepithelium resists the mechanical stresses exerted by dynamic tissue movements through the assembly of cadherin-based cell-cell junctions which are stabilized by the underlying actin cytoskeleton. Failure to establish the cadherin-actin link results in loss of NEP structure and function, thereby giving rise to neural tube defects and cortical malformations. I will describe an unexpected function for the Neogenin axon guidance receptor in maintaining NEP junctional stability by anchoring the actin polymerization machinery (WAVE Regulatory Complex and Arp2/3) to the cadherin adhesion complex. We further show that disrupting Neogenin function in NEPs leads to cortical malformations and hydrocephalus. Our latest studies indicate that a similar mechanism may underpin spine formation and synaptic plasticity.

Directions to UQ

Google Map:
Directions:
St Lucia Campus | Gatton campus.

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