Event Details

Wednesday, 13 June 2018 - Wednesday, 13 June 2018
11:00 am - 12:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
3346 6300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Dr Alessandra C. Martini - Institute for Memory Impairments and Neurological Disorders
University of California - Irvine (UCI)

Title: Amyloid-beta impairs interleukin-1β signaling: impact on Alzheimer’s Disease

Abstract: Inflammation is a fundamental protective response, but if it becomes dysregulated it can be a major cofactor in the pathogenesis of many chronic human diseases, including Alzheimer disease (AD). Interleukin-1β (IL-1β)-mediated chronic inflammation represents a key mechanism by which Aβ drives the development of synaptic impairment and cognitive decline in AD. The pro-inflammatory activities of IL-1β are regulated at three levels: synthesis and release; activation/degradation of the membrane receptor; and intracellular signal transduction, all of which are tightly controlled to ensure proper activation and resolution of immune responses. The disruption of these processes may cause excessive inflammatory responses, however, the underlying mechanisms by which Aβ modulates IL-1β signaling remain unknown. We aim to evaluate if changes in intracellular protein clearance and trafficking are early Aβ-triggered events leading to exacerbated IL-1β-mediated inflammation, which in turn elicits tau pathology, synaptic dysfunction and cognitive decline.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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