Event Details

Friday, 11 May 2018 - Friday, 11 May 2018
11:00 am - 12:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
3346 6300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Professor Jonathon Howard - Eugene Higgins Professor of Molecular Biophysics & Biochemistry, Yale University, USA

Title: “Dendritic Branching Morphogenesis: Motors and Cytoskeleton'

Abstract: The architecture of the brain and its constituent neurons is staggeringly complex. Much of this morphological complexity arises at the cellular level in the form of highly branched dendrites, which enable neurons to receive input from hundreds to hundreds of thousands of other neurons. Our goal is to understand the cell biological principles underlying the branching morphogenesis of dendrites. We are using highly branched mechanoreceptors in fly embryos and larvae as a model system. Using RNAi and CRISPR we have shown that the microtubule cytoskeleton plays a fundamental role in branching, and that mutations can both increase and decrease the complexity of branching. We have discovered that dendrite growth is a highly dynamic process in which individual processes undergo stochastic conversion between rapidly growing and shrinking phases. Theory and simulations show that these local rapid dynamics can give rise to the much slower expansion of the entire dendritic arbor.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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