IMB Seminar Series - Professor Bernie Degnan - Origin of animal multicellularity and complex differentiation landscapes
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- Origin of animal multicellularity and complex differentiation landscapes
The shared ancestor of all living animals minimally possessed epithelial and mesenchymal cell types that could transdifferentiate over an ontogenetic life cycle. This capacity to develop and differentiate required a regulatory capacity to control spatial and temporal gene expression, and included a diversified set of signaling pathways, transcription factors, distal enhancers, promoters and noncoding RNAs. In this seminar, I track the evolution of the regulatory architecture underlying cell differentiation in multicellular animals and provide evidence consistent with the first animal cell having a stem-like capacity to transition between multiple differentiated states.
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