Event Details

Wednesday, 04 April 2018 - Wednesday, 04 April 2018
11:00 am - 12:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
YeJin Chai
Queensland Brain Institute, University of Queensland
Title: 'A highly Munc18-ocentric Hitchhiker's Guide to the Galaxy'
Neurons communicate through the release of neurotransmitter stored in synaptic vesicles located in nerve terminals. Several key molecules such as STXBP1 (also known as Munc18-1) and the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) control the exocytic fusion of these vesicles with the plasma membrane. Deletion of Munc18-1 not only block neurotransmitter release but also leads to widespread neurodegeneration through unknown mechanism. Munc18-1 de novo heterozygous mutations cause developmental defects and epileptic phenotypes including early infantile epileptic encephalopathy type 4 (EIEE4). The mechanism by which these mutations lead to this pathology is poorly understood, and may involve either haploinsufficiency and/or a gain of pathological function of the mutant allele. In this talk, I will present our recent discoveries suggesting that Munc18-1 human EIEE4 mutants confer a gain of toxic function via protein aggregation-induced neurodegeneration. Furthermore, I will show how the nanoscale organization of Munc18-1 is altered by Munc18-1 EIEE-causing mutant in neurosecretory cells and hippocampal neurons using single-molecule imaging.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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