Event Details

Date:
Wednesday, 04 April 2018 - Wednesday, 04 April 2018
Time:
11:00 am - 12:00 pm
Room:
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
URL:
http://www.qbi.uq.edu.au/neuroscience-seminars
Event category(s):

Event Contact

Name:
Ms Deirdre Wilson
Phone:
66300
Email:
d.wilson5@uq.edu.au
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
YeJin Chai
Queensland Brain Institute, University of Queensland
Title: 'A highly Munc18-ocentric Hitchhiker's Guide to the Galaxy'
Abstract:
Neurons communicate through the release of neurotransmitter stored in synaptic vesicles located in nerve terminals. Several key molecules such as STXBP1 (also known as Munc18-1) and the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) control the exocytic fusion of these vesicles with the plasma membrane. Deletion of Munc18-1 not only block neurotransmitter release but also leads to widespread neurodegeneration through unknown mechanism. Munc18-1 de novo heterozygous mutations cause developmental defects and epileptic phenotypes including early infantile epileptic encephalopathy type 4 (EIEE4). The mechanism by which these mutations lead to this pathology is poorly understood, and may involve either haploinsufficiency and/or a gain of pathological function of the mutant allele. In this talk, I will present our recent discoveries suggesting that Munc18-1 human EIEE4 mutants confer a gain of toxic function via protein aggregation-induced neurodegeneration. Furthermore, I will show how the nanoscale organization of Munc18-1 is altered by Munc18-1 EIEE-causing mutant in neurosecretory cells and hippocampal neurons using single-molecule imaging.

Directions to UQ

Google Map:
Directions:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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