Event Details

Wednesday, 07 March 2018 - Wednesday, 07 March 2018
11:00 am - 12:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
3346 6300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Casey Linton, Queensland Brain Institute, University of Queensland

Title: 'Function and regulation of the fusogen EFF-1 during axonal repair'

Achieving repair of the nervous system is an enduring clinical problem, and treatment options for spinal cord and peripheral nerve injuries remain limited.  Discovering novel mechanisms of nerve regeneration is crucial for developing new therapies.  We have characterised a means of axonal repair called axonal fusion, which occurs spontaneously in a number of invertebrate species, including the nematode C. elegans.  Following laser-induced axotomy, the regrowing axonal fragment is able to directly reconnect and fuse with its own severed fragment, re-establishing the original tract and restoring function.  Remarkably, this regenerative process is mediated by EFF-1, a member of the fusogen family of molecules, which acts as the final effector to merge the two axonal membranes.  In this talk, I will present our characterisation of how EFF-1 mediates axonal repair, how it functions within distinct genetic pathways and undergoes spatiotemporal regulation to achieve axonal fusion. These findings are the first step towards translating axonal fusion into a clinical setting, and have exciting implications.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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