Hypoproliferative Anaemias

  • A pathological depression of all cellular elements of peripheral blood

Causes

Bone Marrow (BM) Production Decrease

  • Classical cause of pancytopaenia
      eg. Aplastic Anaemia

Infiltration or Replacement of normal cells

      eg. Acute leukaemia
      Malignancy - lymphomas (may metastasize to the bone marrow
      Myelofibrosis - fibrosis of the BM
      Hairy cell leukaemia

Hypersplenism

  • Large, overactive spleen that allows stagnation of pooled of blood

Immune Destruction

  • Systemic Lupus Erythematosus (SLE) - a classical autoimmune disease

Ineffective Erythropoiesis

  • Megaloblastic anaemia (defective DNA synthesis)
  • Dyserythropoiesis - myelodysplastic syndrome (qualitative abnormalities of one or more cell lines in the peripheral blood)
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