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| 2007 | Crane, J. W. and Buller, K. M. (2007) Systemic blockade of complement C5a receptors reduces lipopolysacharride-induced responses in the paraventricular nucleus and the central amygdala. Neuroscience Letters, 424 1: 10-15. |
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The complement anaphylatoxin C5a is a potent mediator of the innate immune response to. infection. Recent evidence also reveals that C5a contributes to central nervous system effects in addition to its well-known peripheral functions. However, it is not known if C5a has a role in the activation of the hypothalamic-pituitary-adrenal (HPA) axis; a critical cascade that exemplifies neuroimmune interactions between the periphery and the brain. In the present study we examined if systemic pre-treatment with a C5a receptor antagonist, PMX53, can affect lipopolysaccharide-induced (LPS; 1 mg/kg, i.p.) activation of the HPA axis in the rat. Using Fos protein as a marker of neuronal activation, we found that systemic administration of PMX53 reduced the LPS-induced activation of paraventricular corticotropin-releasing factor (PVN CRF) and central amygdala cells. However, PMX53 did not alter LPS-induced responses in the bed nucleus of the stria terminalis, nucleus tractus solitarius and ventrolateral medulla. Our findings demonstrate that C5a may have a role in the activation of the HPA axis in response to systemic LPS. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
| |  Dr James Crane,  Dr Kathryn Buller | | eSpace Record: |
http://espace.library.uq.edu.au/view/UQ:130181
| | | | | Links: | Article DOI - full text from publisher |
| Keywords: | Central amygdala, Complement C5a, Hypothalamicpituitaryadrenal axis, Lipopolysaccharide, Paraventricular nucleus, PMX53 | | |
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