Topical Drug Delivery Group

	Profile

The Topical Drug Delivery Group is a sub-unit of the Therapeutics Research Unit.

The group’s interests range from practical aspects of drug delivery system design through to theoretical investigation and mathematical modelling of penetration and distribution of solutes within various skin layers.

Publications arising from our work have dealt with the relationships between physical or chemical properties of topically applied drugs and their distribution within the skin, as well as the effect of various skin pre-treatments on subsequent drug permeation. The group has also published invited reviews on factors influencing the formation of drug reservoirs within the skin following topical application and the latest developments in physical forms of topical drug delivery, such as jet injectors and electrically-enhanced permeation technologies.

Areas of Research include:

• Effect of drug and cosmeceutical structure on skin permeability kinetics


• Effect of vehicle/formulation on skin absorption


• Targeting of drugs and cosmeceuticals into hair follicles


• Enhancement of drug and cosmeceuticals delivery using physical techniques (iontophoresis, sonophoresis, abrasion)


• Physiological factors affecting drug and cosmeceuticals distribution in the skin


• Effect of blood flow on drug and cosmeceuticals clearance from the skin and tissue distribution


• Prediction and modeling of drug and cosmeceuticals skin penetration kinetics


• Effect of various skin diseases on drug and cosmeceutical absorption

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