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The Centre for Magnetic Resonance is a world-class facility, housing the most comprehensive range of magnetic resonance instrumentation in the southern hemisphere. The Centre for Magnetic Resonance manages the most comprehensive range of magnetic resonance instrumentation in the southern hemisphere. This includes: Bruker 900 MHz and 750 MHz high resolution spectrometers; Siemens 4T and 1.5T scanners located at a major Brisbane private hospital, a Bruker S200 2T scanner; a 16.4T microimaging facility, a multifrequency pulsed FT EPR/ENDOR/ELDOR spectrometer; various animal and materials imaging systems, and solids and solution state NMR spectrometers. These facilities are utilised by research programs across a broad spectrum of applications, from the physico-chemical to biomedical sciences. Facilities and expertise are available to external users for chemical and biochemical analysis, preclinical and clinical drug trials and other research activities.
Centre staff conduct research into the following life sciences areas:
Alzheimers disease imaging of people with dementia of Alzheimers type to measure changes within the brain
cardiac using MRI to tag heart muscles in order to measure myocardial strain
diabetes using MRI to compare subcutaneous fat and internal fat deposits in the liver, calf and abdomen, and measure the effect of an antidiabetic drug on these fat deposits
stroke using diffusion weighted imaging and perfusion imaging to detect stroke lesions and examining their potential to predict final infarct volume
head trauma application of MRI to study head trauma and treatment
functional magnetic resonance imaging (FMRI) can be used to measure areas of activation within the brain
diffusion weighted imaging to examine de- and re-myelination in experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)
biomacromolecular high resolution NMR for structural and functional studies of proteins and nucleic acids and their interactions with potential drug candidates.
plant natural products identification of natural products obtained from plant extracts
biological electron paramagnetic resonance (EPR) spectroscopy application of EPR to biological systems such as the mechanism and role of the enzyme, dimethyl sulfoxide (DMSO) reductase
biomaterials structure and utilisation of synthetic biomaterials for medical applications.
The facilities of the Centre are available for use by researchers who may wish to participate in collaborative research with scientists from the Centre, or use the facilities independently to aid their own research.
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