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 | Biography |  |
Target hair follicles in developing a novel treatment for common skin diseases such as hair loss, acne and rosacea. Common skin diseases such as hair loss, acne, and rosacea are disorders associated with hair follicles. Targeting these hair follicles has become a focus in developing a novel treatment for these skin diseases. It is important to understand the factors that influence the drug delivery into hair follicles to design optimised formulations. New prospects of this field have introduced non-invasive physical enhancements (e.g. massage) and artificial carriers (e.g. oil-based vehicle) that can further enhance the penetration. This study would assist in better treatments for patients with hair follicle related diseases.
My project aims are:
1. To study the factors those influence the partitioning and rate of penetration of a topically applied drug between skin and hair follicle.
2. To define solute structure and vehicle properties that enable specific targeting of topically applied drugs into hair follicles (vehicle lipophilicity, excipient choice, drug physicochemical properties such as molecular size and degree of ionization).
3. To examine whether physical penetration enhancements (ultrasound, abrasion, iontophoresis and tape stripping etc.) can further optimise follicular drug delivery.
4. To examine if new technologies (nanoparticles, liposome, nanosome, ethosome etc) can enhance follicular drug delivery selectively.
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