Metabolism and nutrition.
A stable body weight results from balancing energy intake and expenditure. Changing body weight by diet control or exercise alone is not easy and an imbalance may result in obesity or anorexia. The interactive metabolic effects of exercise and nutrition are being studied in a rat model of anorexia.
Epidemiological evidence suggests an association between exercise and tumourogenesis in man. This research programme, in association with Dr Reilly, is investigating the hypothesis that exercise may decrease the conversion of pre-neoplastic foci to frank tumours via an immune-mediated mechanism. A rat model of liver tumourogenesis is being used.
A major international collaborative research programme is the development of bioelectrical impedance spectroscopy for the measurement of body and tissue fluid volumes in vivo. This work involves theoretical studies, laboratory experimentation and clinical studies in a wide variety of fields, eg. nutritional support in HIV-AIDS, lymphoedema, perinatal medicine and animal production. This has led to the development of commercial instrumentation.