Nanoelectrochemistry, Nanobiosensor, Microfabricated device
I graduated with BSc Hons and MSc (ShahJalal University of Science and Technology, Bangladesh) in 1998 and 1999 and my PhD in 2007 from Pusan National University (S. Korea). Shortly thereafter, I moved to Monash University (Advisor: Prof Alan M Bond) as a Postdoc, where I worked on the development and application of modern electroanalytical techniques. In September 2010, I received UQ postdoctoral Research Fellowship from The University of Queensland, where I worked on the development of microfluidic technology for circulating tumor cells/protein biomarker isolation and detection with Prof Matt Trau. I commenced an ARC DECRA (DECRA, Discovery Early Career Researcher Award) fellowship in March 2012. Previously I received several academic/research fellowships/grants including "Graduate Student Award" from Pusan National University (S. Korea), Monash University Postdoctoral Research Fellowship (2007-2010) from Monash University (Victoria, Australia), and UQ Early Career Researcher Grant (2011) from The University of Queensland (Queensland, Australia).
• Anal. Chem. 2012, 84, 6686–6692.
• Chem. Commun., 2012, 48, 6411-6413.
• Langmuir, 2011, 27, 10302–10311.
• J. Am. Chem. Soc., 2010, 132, 10053–10063.
• Inorg. Chem., 2010, 49, 2502–2511.
• Anal. Chem., 2010, 82, 1680–1691.
• J. Am. Chem. Soc., 2009, 131, 7976–7989.
• Anal. Chem., 2007, 79, 6886–6890.
• Anal. Chem., 2007, 79, 3724–3733.
• Anal. Chem., 2006, 78, 6809–6817.
Available Projects for Honours and PhD Students:
1) Microfluidic Devices for Capturing Rare Circulating Tumour Cells
As cancer mortality rates continue to rise, the national impact of the cancers is beginning to overwhelm healthcare services. The progression of cancer in patients is characterized by cells that invade locally and metastasize to nearby tissues or travel through the blood stream to set up colonies in the other parts of the body. These cells, accounting for 1 or fewer cells in 10^5 – 10^6 peripheral blood mononuclear cells, are known as circulating tumour cells (CTCs). Development of advanced technology for capturing CTCs in blood in the early stage of the metastasis process would be transformative in the treatment of cancer. This project strives to build and test a microfluidic device with the capacity to enable selective capture and sensitive detection of CTCs by incorporating three-dimensional microstructured electrodes within the detection/capture domain of the device.
2) Nanodevices/Nanobiosensors for Cancer Biomarker Proteins
The clinical use of immunoassays in treatment of cancer at early stages of the disease requires detection of proteins of typically 10^-16 to 10^-12 M concentration in whole blood, blood plasma or serum samples. Detecting this low concentration of proteins is potentially useful for identifying individuals at risk and for clinicians to prescribe preventive measures for these individuals. Current immunoassay technologies typically measure the proteins at concentration above 10^-12 M. The development of a detection method that is rapid, cheap, and more sensitive than those currently available could revolutionize many medical treatments in areas such as cancer. In this project, we aim to fabricate nanobiosensors with nanostructured 3D-electrodes to detect single protein molecules in blood.
Via these projects, students will achieve hands on experience in the design, fabrication and application of the microfluidic devices and electrochemical micro(nano)biosensors.