| Summer project | What makes enzymes tick? Detailed characterisation of the electrostatics of a protein folding catalyst with NMR spectroscopy |
| | This project involves the detailed characterisation of an enzyme that catalyses the folding of other proteins in Escherichia coli. By using NMR spectroscopy and modelling, we try to understand the electrostatic interaction within the active site of the enzyme and gain a deeper understanding of its biophysical properties and mechanism of action. |
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| Summer project | Solving the puzzle of metabolic pathways with NMR metabonomics |
| | We try to understand how disease affects the metabolism of an individual. This information can potentially not only used for diagnosis or monitoring how effective a particular disease treatment is, by understanding the metabolic consequences of a disease we might learn something about the mechanism of a particular disease itself. I have several projects available in this area, focussing on a variety of model diseases.
Some of our animal model systems are very well understood, and in these cases we are trying to take the next step by investigating the connection between genotype and phenotype on a systematic level. |
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| Summer project | Development of bioinformatics tools and computational algorithms for NMR metabonomics |
| | The practical use of NMR metabonomics involves the analysis of a multitude of NMR spectra and correlation of these data with other data from physiology, biochemistry, or clinical assessments. This multimodal analysis is at the cutting edge of systems biology and requires the development of novel analytical tools and techniques. Students with an interest or background in mutivariate statistics, programming and/or bioinformatics are highly welcome in this environment. |
