Molecular targets in cancer; Nutritional bioactives in tropical fruit; Mechanism of action of breast cancer risk factors, calcium transport in lactation
Sarah Roberts-Thomson joined the School in 1998 following two and a half years at the prestigious National Cancer Institute in the USA as a Fulbright and Fogarty Postdoctoral Fellow. Since her appointment at the University of Queensland, Dr Roberts-Thomson has established a successful research program gaining over 1.8 million in research funding. She teaches across all streams in the Pharmacy degree and is responsible for teaching the Pharmaceutical Biotechnology and Cancer components of the course. Dr Roberts-Thomson is an active member of many pharmacy professional and scientific societies both international and national. In 2001 she was the Scientific Program Chair for the International Congress of Toxicology IX.
Dr Roberts-Thomson leads a large group of Research Higher Degree students and in 2006 was awarded a meritorious certificate for her Research Higher Degree supervision and in 2007 recieved the award for Excellence in Research Higher Degree Supervision.
Dr Roberts-Thomson's research focuses on the identification and molecular/functional characterization of novel drug targets in breast and colon cancer, and the role of calcium transporters in mammary gland development and lactation.
Selected Recent Publications
GR Monteith, D McAndrew, HM Faddy, SJ Roberts-Thomson. Calcium and Cancer: Transporters as Targets. Nature Reviews Cancer. 7:519 – 530, 2007
Vetter I, Cheng W, Peiris M, Wyse BD, Roberts-Thomson SJ, Zheng J, Monteith GR, Cabot PJ. Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. J Biol Chem. 283:19540-50. 2008
Wilkinson AS, Monteith GR, Shaw PN, Lin CN, Gidley MJ, Roberts-Thomson SJ. Effects of the Mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator- activated receptor isoforms. J Agric Food Chem. 56:3037-42. 2008
WJ Lee, GR Monteith and SJ Roberts-Thomson. Calcium transport and signaling in the mammary gland: targets for breast cancer. BBA- Reviews on Cancer 1765(2):235-55, 2006
CS Aung, HM Faddy, EJ Lister, GR Monteith, Sarah J Roberts-Thomson. Isoform specific changes in PPARa and b in colon and breast cancer with differentiation. Biochem Biophys Res Commun 340:656-60, 2006
Lee WJ, Robinson JA, Holman NA, McCall MN, Roberts-Thomson SJ, Monteith GR. Antisense-mediated Inhibition of the Plasma Membrane Calcium-ATPase Suppresses Proliferation of MCF-7 Cells. J Biol Chem. 280:27076-84, 2005