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 | Biography |  |
Plant Molecular Biology and Structural Biology Dr Mylne holds an ARC Queen Elizabeth II Fellowship currently hosted by Prof. David Craik at the IMB in Brisbane. He completed his PhD in 2002 at the University of Queensland Botany Department and thereafter took up a post-doctoral position with Prof. Caroline Dean of the John Innes Centre in England where, for the next four years, he used molecular genetics to study the genes involved in flowering time and the epigenetic process vernalization. Early in 2006 he was recruited to the IMB structural biology department where he now pursues applied work developing plants as a production system for cyclic peptide drugs and is also acquiring new skills in NMR and protein biochemistry which he is beginning to apply to basic research on Arabidopsis proteins involved in vernalization.
Publications (2002-2010)
Mylne, Wang, Van der Weerden and Craik. 2010. Cyclotides are a component of the innate defence of O. affinis. Biopolymers (Pept. Sci.) on-line May 26.
Qin, McCallum, Kaas, Saska, Craik, and Mylne. 2010. Identification of candidates for cyclotide biosynthesis and cyclization by expressed sequence tag analysis of O. affinis. BMC Genomics. 11: 111.
Craik, Mylne, and Daly. 2010. Cyclotides: macrocyclic peptides with applications in drug design and agriculture. Cell. Mol. Life Sci.. 67: 9-16.
Trabi, Mylne, Sando, and Craik. 2009. Circular proteins from Melicytus refine the conserved protein and gene architecture of cyclotides. Organic & Biomolecular Chemistry. 7: 2378 – 2388.
King, Hill, Martin, and Mylne. 2009. Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1208-341 from A. thaliana. Acta Crystallogr. F65: 291-294.
Mylne and Craik. 2008. 15N cyclotides by whole plant labeling. Biopolymers (Pept. Sci.) 90: 575-580.
Pien, Fleury, Mylne, Crevillen, Inzé, Avramova, Dean, and Grossniklaus. 2008. ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation. Plant Cell 20: 580-588.
Herrmann, Burman, Mylne, Karlsson, Gullbo, Craik, Clark, and Göransson. 2008. The alpine violet, Viola biflora, is a rich source of novel cyclotides with potent cytotoxicity. Phytochemistry 69: 939-952.
Greb*, Mylne*, Crevillen, Geraldo, An, Gendall and Dean. 2007. The PHD finger protein VRN5 functions in the epigenetic silencing of Arabidopsis FLC. Current Biology 17: 73-78. (*joint first author)
Mulvenna, Mylne, Bharathi, Burton, Shirley, Fincher, Anderson and Craik. 2006. Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins? Plant Cell 18: 2134-2144.
Mylne, Barrett, Tessadori, Mesnage, Johnson, Bernatavichute, Jacobsen, Fransz and Dean. 2006. LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1 is required for epigenetic silencing of FLC. Proc. Natl Acad. Sci. U.S.A. 103: 5012-5017.
Petsch, Mylne and Botella. 2005. Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division. Plant Physiology 139: 115-126.
Mylne, Greb, Lister and Dean. 2004. Epigenetic Regulation in the Control of Flowering. in Epigenetics, eds. Stillman & Stewart (CSHL Press, Cold Spring Harbor, New York), Vol. LXIX, pp. 457–464.
Bastow, Mylne, Lister, Lippman, Martienssen, and Dean. 2004. Vernalization requires epigenetic silencing of FLC by histone methylation. Nature 427: 164-167.
Boss, Bastow, Mylne, and Dean. 2004. Multiple pathways in the decision to flower: enabling, promoting, and resetting. Plant Cell 16: S18-31.
Levy, Mesnage, Mylne, Gendall, and Dean. 2002. Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control. Science 297: 243-246.
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| Vernalization doses
fca-1 vs vrn1-2 fca-1 and their vernalization response to increased periods of cold | | |
| SFTI-1 letters
Sunflower trypsin inhibitor 1 (SFTI-1) is a 14 amino acid cyclic peptide from sunflower seeds. |
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