Greg studies cellular signalling in disease and the identification of new drug targets.
Following his PhD at the University of Sydney, Greg spent two years at the University of Maryland at Baltimore (USA) in the Department of Physiology, developing novel techniques for the assessment of calcium (Ca2+) in sub-cellular organelles. Since his appointment at the University of Queensland, Greg has established a research program with research funding via NHMRC and National Heart Foundation, Queensland Cancer Fund, Society of biomolecular Screening (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. In 2006 he recieved a UQ Foundation research excellence award.
Feng M, Grice D, Faddy H, Nguyen N, Leitch S, Wang Y, Muend S, Kenny P, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R. Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors. Cell. 143: 84-98. 2010
Roberts-Thomson SJ, Peters A, Grice D, Monteith GR. ORAI1 mediated calcium influx: pharmacology and pathophysiology. Pharmacol Ther.;127(2):121-30, 2010
Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, Monteith GR. The Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. Journal of Biological Chemistry. 2010
Monteith GR, McAndrew D, Faddy HM. Roberts-Thomson SJ. Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer. 2007. 7, 519-530.
Kruger WA, Yun CC, Monteith GR, Poronnik P. Muscarinic-induced recruitment of plasma membrane Ca2+-ATPase involves PSD-95/Dlg/Zo-1-mediated interactions. J Biol Chem. 284:1820-30. 2009
Vetter I, Cheng W, Peiris M, Wyse BD, Roberts-Thomson SJ, Zheng J, Monteith GR, Cabot PJ.
Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization.
J Biol Chem. 283:19540-50. 2008
Wilkinson AS, Monteith GR, Shaw PN, Lin CN, Gidley MJ, Roberts-Thomson SJ. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 56(9):3037-42. 2008
Lee WJ, Robinson JA, Holman NA, McCall MN, Roberts-Thomson SJ, Monteith GR. Antisense Mediated Inhibition of the Plasma Membrane Calcium-ATPase Suppresses Proliferation of MCF-7 Cells. J. Biol. Chem. 2005. 280:27076-84.
Lee WJ, Monteith GR and Roberts-Thomson SJ. Calcium transport and signaling in the mammary gland: targets for breast cancer. BBA reviews on Cancer. 2006. 340:656-660.
Monteith GR, Bird GS. High-throughput measurement of intracellular Ca(2+) -- back to basics. Trends Pharmacol Sci. 2005 26:218-23.
Robinson JA, Jenkins NS, Holman NA, Roberts-Thomson SJ, Monteith GR. Ratiometric and nonratiometric Ca2+ indicators for the assessment of intracellular free Ca2+ in a breast cancer cell line using a fluorescence microplate reader. J Biochem Biophys Methods. 2004 58:227-37
||Science and Technology: Signal Transduction (Sensory/Cellular), Science and Technology: Cellular Physiology, Medical: Screening of Drugs/Agents, Medical: Pharmacy, Medical: Pharmacology, Medical: Pharmaceuticals, Medical: Neuropharmacology, Medical: Molecular Probes, Medical: Cell Lines, Medical: Breast Cancer, Medical: Bioassay, Medical: Cancer Biology