Group Leader, Electron Paramagnetic Resonance (EPR) Research Group
Professor Hanson is the Group Leader of the Electron Paramagnetic Resonance (EPR) Research Group. His major research interests include continuous wave and pulsed EPR spectroscopy, its application to the characterisation of paramagnetic materials with special emphasis on the analysis of CW and pulsed EPR spectra and the metal binding sites in metalloproteins and transition metal ion complexes. He is committed to maintaining a world class EPR facility and providing expertise in EPR spectroscopy to users within and outside the University of Queensland. Towards this end my group have, over the last three years, undertaken the development of an integrated approach (Molecular Sophe) based on molecular structure for the analysis of continuous wave and pulsed EPR and ENDOR spectra, energy level diagrams, transition roadmaps and transition surfaces. This approach, will revolutionise the 3-dimensional molecular characterisation of paramagnetic materials using EPR spectroscopy and employs a completely new graphical user interface, the SOPHE grid (patented), the mosaic misorientation linewidth model, frequency domain pulsed simulations, Floquet theory and distributions of spin Hamiltonian and structural (internuclear distances and orientations) parameters. Molecular Sophe v2.1 is now available commercially through Bruker Biospin. Multifrequency CW-EPR and pulsed EPR have been employed in the characterisation of metal binding sites in molybdoenzymes (xanthine oxidase, DMSO reductase, DMS dehydrogenase), iron sulfur proteins (lactyl dehydratase, Giardia ferredoxin), metallo-substituted enzymes (carboxypeptidase A, phospholipase C) purple acid phosphatases and marine cyclic octapeptides. I am currently coeditor with Prof, Larry Berliner of two volumes of Biological Magnetic Resonance entitled: High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine and Metals in Biology: Application of High Resolution EPR to Metalloenzymes.
Prof Graeme Hanson