Associate Professor Luke Guddat - UQ reSEARCHers (Publications)

	Publications

	2012	A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
	2012	Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases
	2012	Identification of purple acid phosphatase inhibitors by fragment-based screening: Promising new leads for osteoporosis therapeutics
	2012	Penicillin inhibitors of purple acid phosphatase
	2012	The structure-activity relationship in herbicidal monosubstituted sulfonylureas
	2012	Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents
	2012	Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction
	2012	Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter
	2011	Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases
	2011	Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives
	2011	6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs
	2011	Drug targets for the treatment of protozoan parasitic diseases
	2010	Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
	2010	The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis
	2009	Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
	2009	Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics
	2009	Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)
	2009	Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures
	2009	Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase
	2009	Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids
	2009	Snake venom nerve growth factors
	2008	Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes
	2008	Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?
	2008	Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle
	2008	Structure and mechanism of inhibition of plant acetohydroxyacid synthase
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