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 | Biography |  |
Molecular mechanisms of oxidative stress toxicity and longevity Genetic mapping of oxidative stress resistance genes. The fumigant, phosphine, disrupts oxidative metabolism, resulting in the production of reactive oxygen intermediates. This causes the premature ageing and death of targeted pests. Insect pests of stored grain in Australia now exhibit resistance to phosphine at levels more than 200 times the normal lethal dose.
We are using genetic mapping to clone the genes responsible for phosphine resistance in the Lesser Grain Borer.
We are also using functional genomics of the model organisms C. elegans to understand the molecular basis of phosphine action
Our genetic studies have recently shown that resistance to phosphine is associated with an extension of lifespan
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Medical: Genomics, Medical: Bioinformatics, Science and Technology: Molecular Genetics, Science and Technology: Genetics, Science and Technology: Entomology, Science and Technology: Nematology, Science and Technology: Invertebrate Physiology, Agricultural: Grain Processing/Storage, Agricultural: Pesticides, Agricultural: Pest Management, Science and Technology: Mitochondria, Medical: Mitochondrial Disorder, Medical: Aging/Gerontology, Medical: Molecular Cloning, Medical: Metabolism, Medical: Gene Regulation, Science and Technology: Toxicology, Science and Technology: Physiological Processes, Science and Technology: Molecular Biology, Science and Technology: Metabolic Biology, Science and Technology: Cellular Physiology, Medical: Biological Markers, Education: E-Learning, Education: Distance Learning |
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