Mr Andrew Dalley is a Research Officer for the Burns Trauma and Critical Care Research Centre.
Andrew is a practical research scientist with post-doctoral experience of cell biology and analytical techniques in both commercial and academic research settings. His role within the Oral Cancer Research Group is to coordinate laboratory studies and to investigate the potential involvement of epithelial stem cells in pre-malignant oral dysplasia. Andrew employs a range of cell culture systems including 3-dimensional cultures of cells in dermal derived matrices and collagen gels, and applies a number of analytical techniques such as ELISA, flow cytometry, histology and confocal microscopy.
Andrew was previously part of the Burns Trauma & Critical Care Research Centre (BTCCRC) and retains an interest in translational Burns research. His former role within the BTCCRC was to evaluate antibiotic distribution in extensively burned patients. In this role, Andrew performed microdialysis in burned patients during debridement surgery, sample analysis by high-performance liquid chromatography (HPLC) and pharmacokinetic modelling.
Formerly based in the UK, Andrew studied BSc Pharmacology and completed his PhD at The University of Sheffield under supervision from Professor Sheila MacNeil. Andrew’s PhD used 3-dimensional cultures to investigate regulation of normal and scar derived fibroblasts by dermal matrix and epithelial cells. Subsequently, he used in-vitro techniques to monitor the uptake of drugs across the gut mucosa and skin.
Andrew’s research interests include phenotypic and genotypic changes in pre-malignant oral dysplasia, extracellular matrix biology and its involvement in the pathophysiology of burn wound healing, epithelial / mesenchymal interaction across the basement membrane during the healing of cutaneous wounds, and drug distribution in critical patients.