<< Back to Publication List
|2007 ||Riek, S., Hinder, M. R. and Carson, R. G. (2007). Continuous theta burst stimulation of motor cortex and its effect on visuomotor adaptation. In: , 2007 Neuroscience Meeting Planner. Neuroscience 2007: 37th Annual Meeting of the Society for Neuroscience, San Diego, California, U.S.A., (). 3-7 November, 2007.|
We used repetitive TMS to examine the effect of sustained inhibition of the corticospinal pathway on visuomotor adaptation. Eight participants performed an isometric aiming task in 2 sessions, STIM and CONTROL, in which they generated torques in 2 degrees of freedom (elbow flexion/extension, forearm pronation/supination). On each trial, they were required to acquire 1 of 8 visual targets presented around a central starting position, as quickly and accurately as possible. Participants were first exposed to a 30 degree clockwise visuomotor rotation (A), then a 60 degree counterclockwise rotation (B) followed by a second block of 30 degree CW rotation (A2). In the STIM session, participants received 20 s of theta burst stimulation (TBS - 80% of active motor threshold) prior to exposure to the initial A block to induce inhibition of corticospinal projections to the muscles of the right arm. Single pulse TMS (150% resting motor threshold) was used to monitor motor evoked potentials (MEP) in the right flexor carpi radialis muscle throughout both sessions. Despite a reliable reduction in excitability in the STIM session (reduced MEPs relative to CONTROL), the rate and degree of adaptation to the visuomotor rotations in each block were indistinguishable from CONTROL. These results are discussed in terms of the role of motor cortex in internal model formation and consolidation.
| Professor Richard Carson, Dr Stephan Riek|
|eSpace Record: |
| || |