Dr Thiruma (Garrie) Arumugam

Position

ARC Future Fellow

Senior Lecturer

Qualifications and Awards

BMedSc (Hons) USyd, PhD UQ

Associations

Society for Neuroscience

Contact Details

Location Room 318, Skerman Building (No 65), St Lucia campus
Mail School of Biomedical Sciences,
The University of Queensland,
BNE, QUEENSLAND 4072
Telephone +61 3365 2299
Facsimile +61 7 3365 1766
Email t.arumugam@uq.edu.au

Biography

Dr Thiruma V. Arumugam (Garrie) received his Bachelor's of Medical Science (Hons) from the University of Sydney and a Ph.D. in Pharmacology from the University of Queensland. He moved to Louisiana State University Health Sciences Center in Shreveport, Louisiana in 2003 to complete a Post Doctoral fellowship with the highly cited Professor D. Neil Granger on the role of T cells in Stroke. Dr. Arumugam then accepted a Post Doctoral position in the laboratory of highly cited Professor. Mark P. Mattson's at the National Institute on Aging, NIH, where he studied the novel mechanisms of ischemic stroke injury. After 3 years of training at NIH, Dr Arumugam took a tenure-earning faculty position in the Department of Pharmaceutical Sciences at the Texas Tech University Health Sciences Center (2007-2009). Dr Arumugam moved to Australia and began as a senior lecturer at the UQ School of Biomedical Sciences, in January 2009.

Research Interests

Mechanisms of Ischaemic Stroke: Ischaemic stroke is a devastating disease that represents the second leading cause of death in Australia. Ischaemic stroke causes damage and death of neurons in the perfusion territory of the affected blood vessel. The neurodegenerative mechanism involves metabolic and oxidative stress, excitotoxicity and apoptosis, and inflammatory processes including microglia activation and infiltration of activated leukocytes.

A primary focus of our laboratory is to understand the cellular and molecular mechanisms and to study therapeutic targets to treat ischaemic stroke injury. Toward this end, we have developed in vitro and in vivo models of ischaemic stroke.

Selected Publications

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP. Nature Medicine 2006; 12(6):621-3.

Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Arumugam TV, Tang SC, Lathia JD, Cheng A, Mughal MR, Chigurupati S, Magnus T, Chan SL, Jo DG, Ouyang X, Fairlie DP, Granger DN, Vortmeyer A, Basta M, Mattson MP. The Proceedings of the National Academy of Sciences (USA) 2007; 104(35):14104-9.

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP. Nature Neuroscience 2008; 11(3):309-17

Age and Energy Intake Interact to Modify Multiple Cellular Stress Response Pathways Involved in Ischemic Stroke Outcome. Arumugam TV, Phillips TM, Cheng A, Morrell CH, Mattson MP, Wan R.
Annals of Neurology 2010; 67(1):41-52.

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, Jo DG, Lathia JD, Siler DA, Chigurupati S, Ouyang X, Magnus T, Camandola S, Mattson MP. The Proceedings of the National Academy of Sciences (USA) 2007; 104(34):13798-803

Role of T lymphocytes and interferon-gamma in ischemic stroke. Arumugam TV*, Yilmaz G*, Stokes KY, Granger DN. *Equal Contribution Circulation 2006; 113(17):2105-12.

Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. Cheng A, Arumugam TV, Liu D, Khatri RG, Mustafa K, Kwak S, Ling HP, Gonzales C, Xin O, Jo DG, Guo Z, Mark RJ, Mattson MP. Journal of Neuroscience 2007; 27(7):1519-28.

Toll-like receptors in neurodegeneration. Okun E, Griffioen KJ, Lathia JD, Tang SC, Mattson MP, Arumugam TV. Brain Research Reviews 2009; 59(2):278-92.

Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke. Lathia JD, Chigurupati S, Thundyil J, Selvaraj PK, Mughal MR, Woodruff TM, Chan SL, Karamyan VT, Mattson MP, Arumugam TV. Experimental Neurology 2010; 221(1):107-14.

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death Thundyil J, Tang SC, Okun E, Shah K, Karamyan VT, Li YI, Woodruff TM, Taylor SM, Jo DG, Mattson MP, Arumugam TV. Experimental & Translational Stroke Medicine 2010; 2:15

Grants

CIA: Role of FcR in Ischaemic Stroke Induced Neuronal Cell Death
Grant Body: UQ ECR
Grant Period: 2010-2011
Value: $32,000

CIA: Role of Adiponectin in Ischaemic Stroke Induced Neuronal Cell Death
Grant Body: UQ NSRSF
Grant Period: 2009-2010
Value: $12,000

CIA: Notch-NFkappaB in Neuronal Cell Death
Grant Body: Australian Heart Foundation
Grant Period: 2010-2011
Value: $129,000

CIA: Gamma-Secretase inhibitors as novel pharmacological agents to target stroke induced brain injury
Grant Body: NH&MRC
Grant Period: 2011-2013
Value: $ 426,273

CIA: Novel pharmacological agents to target stroke induced brain injury
Grant Body: ARC (Future Fellowship)
Grant Period: 2011-2014
Value: $706,552

CIB: TNF traffic and secretion in astrocytes and microglial cells
Grant Body: NH&MRC
Grant Period: 2011-2013
Value: $ 565,048

CIB: A systems biology approach to elucidate triplet repeat expansion associated genetic defects
Grant Body: NH&MRC
Grant Period: 2011-2013
Value: $ 726,284

CIC: Does a Novel Estrogen Receptor Worsen Stroke Outcome?
Grant Body: NH&MRC
Grant Period: 2011-2013
Value: $ 506,706

CIC: Aldosterone and the Mineralocorticoid Receptor in Cerebrovascular Disease
Grant Body: Australian Heart Foundation
Grant Period: 2011-2012
Value: $129,000

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