Dr Tamara Paravicini

Position

Lecturer  

Qualifications and Awards
 
 BSc (Hons), Pharmacology, Monash University 2000
PhD (Pharmacology), The University of Melbourne 2005
  
Contact Details

Location Room 716, Otto Hirschfeld Building 81, St Lucia Campus
Mail School of Biomedical Sciences
The University of Queensland,
BNE, QUEENSLAND 4072
Telephone +61 3365 1943
Facsimile +61 3365 1040
Email t.paravicini@uq.edu.au

Biography
 
I received my PhD from the University of Melbourne in 2005. My PhD studies focused on the functional role of reactive oxygen species in the cerebral circulation, with a particular emphasis on how such molecules may contribute to the pathogenesis of diseases such as hypertension, stroke, and atherosclerosis. Following completion of my PhD I was awarded a National Heart Foundation Overseas Research Fellowship to continue my research at the Kidney Research Centre/Ottawa Health Research Institute in Canada. Whilst in Canada I broadened my research focus to include the role of novel magnesium channels in vascular physiology, and received funding from the Heart and Stroke Foundation of Canada for this work. In 2009 I moved to UQ, where I currently hold a fellowship from the Foundation for High Pressure Research. My research focuses on identifying the mechanisms underlying vascular remodelling and dysfunction in diseases such as hypertension.
 
Research Interests
 
Broadly, my research focuses on understanding the mechanisms that contribute to the abnormal growth and functioning of the heart and blood vessels during cardiovascular disease. More specifically, my current research interests lie in the area of magnesium transport and signalling in the cardiovascular system. Although known to be critical for cellular function, the mechanisms which underlie magnesium transport and signalling are poorly understood. Recently, the proteins TRPM6 and TRPM7 have been identified as magnesium transporters critical for regulation of both cellular and whole body magnesium homeostasis. These proteins are particularly unique as they act as both ion channels and active signalling kinases that modulate cell growth and viability. Current research projects are aimed at elucidating the molecular mechanisms of TRPM6/7 function and how this may contribute to cardiac hypertrophy and remodeling.
 
Selected Publications
Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause K-H, Lambeth D, Quinn MT, Touyz RM. Nicotinamide adenine dinucleotide phosphate reduced      oxidase 5 (Nox5) regulation by Angiotensin II and Endothelin-1 is mediated via Circulation Research 106:1363-73, 2010

Paravicini TM, Yogi A, Mazur A & Touyz RM (2009). Dysregulation of vascular TRPM7 and annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia. Hypertension 53(2):423-9

Paravicini TM & Touyz RM (2008).NADPH oxidases, reactive oxygen species and hypertension – Clinical implications and therapeutic possibilities. Diabetes Care 31: S170-S180.

Sontia B, Montezano ACI, Paravicini TM, Tabet F & Touyz RM (2008).  Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension 51: 915 – 21. IF = 7.19, NC = 6.

Paravicini TM & Touyz RM (2006). Redox signalling in hypertension. Cardiovascular Research 71(2):247-58.

Paravicini TM, Miller AA, Drummond GR & Sobey CG (2006). Flow-induced cerebral vasodilatation in vivo involves activation of phosphotidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. Journal of Cerebral Blood Flow and Metabolism 26 (6):836-45.

Paravicini TM, Chrissobolis S, Drummond GR & Sobey CG (2004). Increased NADPH oxidase activity and Nox4 expression is associated with enhanced cerebral vasodilatation to NADPH in vivo.  Stroke 35:584-589

Paravicini TM, Gulluyan L, Dusting GJ & Drummond GR (2002).  Increased NADPH oxidase activity, gp91phox expression and endothelium-dependent relaxation during neointima formation in rabbits.  Circulation Research 91:54 – 61
 
Grants
2010 – 2011 Foundation for High Blood Pressure Research Fellowship
2010            UQ Early Career Research Grant ($35,000)
2009            National Heart Foundation Postdoctoral Fellowship (Australian component)
2008            Heart and Stroke Foundation of Canada High Risk Research Grant ($29,250 CAD)
2008            Heart and Stroke Foundation of Canada Postdoctoral Fellowship
2005 - 2007 National Heart Foundation of Australia Overseas Research Fellowship

 

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