Dr Karin Borges
Qualifications and Awards
|Location||Room 423, Skerman Building (No 65), St Lucia campus|
|School of Biomedical Sciences,
The University of Queensland,
BNE, QUEENSLAND 4072
|Telephone||+61 (0)7 3365 3113|
|Facsimile||+61 (0)7 3365 1766|
Dr. Borges studied Biology in at the University of Freiburg (Germany). Studying glutamate receptors in glial cells, she received a PhD in Neurobiology at Heidelberg University in 1994. She continued her education as a postdoctoral fellow at the Department of Pharmacology at Emory University studying the regulation of transcription of the glutamate receptor subunits, GluR1 and GluR4. Since 2001, she has been interested in the morphological and functional changes involved in the development epilepsy as an instructor at Emory University, then as Assistant Professor at Texas Tech University (2005-2008) and now at UQ. Her long-term goal is to find new treatments that are anticonvulsant and can prevent the development of epilepsy after brain insults. To this end she has been receiving several grants from the Epilepsy Foundation, Citizens United for Research in Epilepsy,Epilepsy Therapy Project, NIH and NHMRC and has applied for three patents.
- Anti-inflammatory treatments to prevent seizures and the development of epilepsy
- Development of triheptanoin as a new anticonvulsant treatment - reviewed on Youtube.
- Dr. Borges together with Professor Terence O’Brien, started a clinical trial of triheptanoin in epilepsy patients in July 2012 in Melbourne. The trial is funded by the Epilepsy Therapy Project through the American Epilepsy Research Foundation,
Samala R, Klein J, Borges K. (2011) Neurochemistry International 58: 5-8
Sonnewald, U. and Borges, K. Triheptanoin - a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment? Epilepsy Research, epub 18 Aug 2011
Borges, K., M.Gearing, D.L. McDermott, A.B. Smith, A.G. Almonte, B.H. Wainer and R. Dingledine (2003) Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.
Exp. Neurol. 1882: 21-34
Borges, K., McDermott, D., Irier, H., Smith, R. and R. Dingledine. (2006) Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticu
Exp Neurol 201:416-427
Borges, K., Shaw, R. and R. Dingledine. (2007) Seizure preconditioning changes gene expression mainly within the dentate gyrus granule cell layer. Neurobiology of Disease 26: 66-77
Borges, K., Gearing, M., Rittling, S., Sorensen, E., Kotloski, R., Denhardt, D., and R. Dingledine. (2008) Characterization of osteopontin expression and function after status epilepticus
Samala, R, Willis, S. and Borges, K. (2008) Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models. Epilepsy Research 81:119-27
Willis, S., Samala, R., Rosenberger, T. and Borges, K. (2009). Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia. 50: 138-42
Current Research Collaboration