Brain growth & regeneration

脑的发育和再生

Professor Key Lab -
教授

My lab is studying the olfactory system during growth and regeneration in order to understand the underlying cell and molecular mechanisms that could be applied to brain repair.
For this research we turn to animal models with simple wiring patterns, the zebrafish and Xenopus frog. Our goal here is to understand the 3-dimensional arrangement of cues used in the construction of the brain circuitry and to use this information to assist in the repair of regenerating circuits.
我的实验室是研究嗅觉系统的发育和再生，以理解潜在的可用于脑修复的细胞和分子机制。我们运用斑马鱼和非洲爪蟾的动物模型研究构成脑通路的三位立体排列方式，再将这些信息应用于脑修复。

Projects Available:
课题项目

• Filming axons as they grow in the brain. What can we learn and how can we translate this into a therapeutic advancement?
• 摄片轴突在脑的生长，从中我们能学到什么及如何应用到治疗学里
• How do pioneer axons in the embryonic brain know where to grow?
• 如何知道胚胎期脑的早期轴突在哪里发育
• How to regenerate the mammalian brain?
• 哺乳类动物的脑是如何再生的
• What controls the growth of neurons in the highly plastic olfactory system?
• 在高度可塑的嗅觉系统什么控制神经元的生长
   

Molecular and Cellular Pharmacology – regulation of Phase II enzymes in cancer.
分子和细胞药理学------在癌症中II相酶的调节
Molecular and Cellular Pharmacology – gene delivery and nanoparticles
分子和细胞药理学------基因转导和纳米颗粒

Professor Rod Minchin Lab -
教授

The Molecular and Cellular Pharmacology group studies the regulation of important enzymes such as the Acetyltransferases and Sulfotransferases and their role in cancer.  Projects include their genetic variation in cancer patients, transcriptional and port-transcription mechanisms in their expression, and their interaction with partner proteins in cells.
The group also focuses on novel approaches to DNA delivery for gene therapy using peptide-based carriers and nanomatierials.  These studies aim to understand how large molecules enter cells and how they can be modified for optimum drug and gene delivery
分子与细胞药理学课题组主要研究一些重要的酶如乙酰转移酶和硫酸转移酶的调节及它们在癌症中的角色。课题主要包括它们在癌症病人中的遗传学变异及表达中的转录及部分转录机制，及在细胞中与它们对应蛋白的相互作用。我们课题组也研究一些新颖的DNA转运对应用以肽类为基础的载体和纳米颗粒的基因治疗的作用。目的是搞清大分子如何进入细胞及它们怎样能被修改为适宜的药物和基  因转导。

Projects Available:
 课题项目

• Regulation of human arylamine N-acetyltransferase – role in cancer
• 人N-乙酰基转移酶的调节及在癌症中的角色。
• Interaction of sulfotransferases with the isomerase PIN1 – role in neurodegenerative disease
• 硫酸转移酶与PIN１异构酶的相互作用及在神经变性性疾病中的角色。
• Pharmacogenetics of proteins involved in carcinogen metabolism.
• 致癌物代谢中的蛋白的药物遗传学
• Post-translational regulaton of spermine-spermidine N-acetyltransferase.
• 精胺－亚精胺 N－乙酰转移酶的翻译后调节
• Gene delivery by peptide-based carriers
• 通过基于肽类载体的基因转导。

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Regulation of cell function by affecting membrane receptor, ion channel, & intracellular signalling systems

通过膜受体，离子通道和细胞内信号系统调节细胞功能

Professor Chen Chen Lab -
教授

This group focuses on the fundamental changes in the cell in relation to the function of organs and systems in commonly occurring diseases. The targets under investigation are a wide range from cell membrane proteins to intracellular signaling molecules, and from DNA transcription in cell nuclear to hormone/neurotransmitter released from cell. Cutting-edge technologies enable us to study every steps occurred in single cell with clarify under strictly controlled experimental condition.
我们实验室主要研究与一些常见疾病器官和系统功能相关的细胞的基本改变及从细胞膜蛋白到细胞内分子，从细胞核DNA转录到激素/神经递质的释放。在严格实验条件限制下采用目前最先进的技术，我们可以研究发生在单细胞上的每一环节。

Projects Available:
课题项目

• Membrane ion channels and signalling systems in the regulation of hormone secretion
• 调节激素释放的膜离子通道和信号系统 （糖尿病和肥胖症的细胞病理机制）
• Ion channel and signaling in functional regulation of cardiomyocytes
• 膜离子通道和信号系统在心肌细胞功能调节中的作用 （慢性心力衰竭的治疗研究）

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Molecular, cellular & in vivo studies of G protein-coupled receptors with relevance to cardiovascular disease

与心血管疾病相关的分子，细胞及在体G蛋白藕联受体研究

Professor Walter Thomas Lab -
教授

The Receptor Biology Group focuses on understanding the activation of G protein-coupled receptors (GPCRs) at a molecular and cellular level.  Mutations and modifications of GPCRs and their signalling and regulatory partners are linked to dysfunction and disease and drugs that target these receptors are prime candidates for therapy.  We have a strong international reputation for studying the activation and deactivation of two main, clinically relevant GPCRs – the angiotensin type 1 receptor and urotensin II receptor.  Perturbations in these systems are linked to hypertension and cardiovascular disease.
受体生物学课题组主要在分子和细胞水平研究G蛋白藕联受体（GPCRs），GPCRs的突变与修改及它们的信号和调节模式与机能失调、疾病及作为潜在的药物治疗靶点的受体的关系。在研究两个主要的与临床相关的GPCRs— 血管紧张素Ⅰ型受体和urotensinⅡ受体的激活与失活方面我们享有很高的国际声誉。干预这些系统可能与高血压及心血管疾病相关。

Projects Available:
课题项目

• Cancer-related cell signalling in heart growth and cardiac failure
• 在心脏发育及心衰中癌症相关细胞信号的作用
• Regulation of GPCR activation by proteins termed arrestins
• 通过蛋白捕获调节GPCR的激活
• Identification of new protein-protein interactions in the GPCR complex using a GFP complementation screening approach
• 应用GFP互补筛选的方法鉴定新的GPCR复合体中蛋白与蛋白的相互作用。