US National Institutes of Health – Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) – PAR-19-070
Sponsor: US National Institutes of Health
Closing Date: 11-Mar-2019
The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing research on current topics in Alzheimer's disease and its related dementias. Further information on the high-priority topics of interest will be announced through a series of Notices published subsequent to this FOA.

Update: High-Priority Research Topics
The NIH has specified behavioural and social science priority areas for this FOA through NOT-AG-18-056 and NOT-AG-18-057.

NOT-AG-18-056
For burden of disease factors, research is needed that extends beyond broad societal costs, looking at the entire distribution of individuals affected by the disease rather than population averages. Trends and differences in expenditures and other burdens across regions, household types, socioeconomic statuses, and racial/ethnic groups are thus encouraged. For health outcomes, research is needed to understand the impact of dementia on the person with dementia (e.g., quality of life). It is particularly critical to explore the impacts of dementia on persons living alone, perhaps without a caregiver at all. Research that considers health impacts and how they might shape the relationships between PWD, their families/informal caregivers, paid care providers, and their communities is encouraged. For community support, insufficient research has been conducted to understand the elements of the existing infrastructure (e.g. transportation services, meals on wheels, etc.) that provide necessary support to PWD, caregivers, and their families. Gaps that this initiative could address include determinants of the availability of a range of services for PWD and determinants of service utilization. Intervention development and the identification of new models of care in long-term care settings are also needed.

Observational studies as well as intervention research are encouraged in the following high priority topic areas but are not limited to:
• Identifying which aspects of the community provide support to PWD
Identifying the mechanisms and risk factors that explain disparities in service access and service quality for persons with dementia
• Identifying best models of care in LTSS settings (design, organization, financing) to maintain quality of life for PWD and their caregivers, with particular interest in care coordination
• Identifying how regulatory and economic incentives and constraints affect access, quality, and health outcomes in health and long-term care systems for PWD
• Identifying quality of life and health outcomes for PWDs, with particular interest on those who live alone with dementia
• Identifying PWD outcomes across settings to account for health and quality of life outcomes that can vary along the disease trajectory. Settings to include: home, assisted living, adult day care, respite, nursing homes.
• Identifying how paid care provider training impacts PWD outcomes (e.g., CNAs receiving medication management training)

NOT-AG-18-057
Care and caregiver support intervention research can be for implementation in the home, community, or any formal care or clinical setting. Interventions may be designed to target behavioral, psychological, interpersonal, social, or institutional processes, and they may be focused on the individual, family, dyad, group, community, or health systems level. Applications may propose intervention research for any stage of AD/ADRD. Applicants should specify the disease stage(s), the setting/context, and the population being studied. High-priority topics in this area of research include, but are not limited to:
• Connections between interpersonal dynamics within families or couples and caregiving quality and outcomes in health and well-being;
• Constraints and consequences in the use of formal alternatives to informal caregiving;
• Economic consequences of caregiving on familial well-being and health;
• Improved assessment of caregiving processes and their impact on families and individuals;
• Risk, protective, and resilience factors related to elder mistreatment and interventions to prevent or detect elder mistreatment in informal care settings;
• Non-pharmacological interventions to treat disorders related to caregiver stress or burden;
• Development and testing of technology to enable aging in place, engage persons with AD/ADRD and their caregivers, and to reduce hospitalization, emergency room visits, and admissions to long-term care facilities; and
• The demography of AD/ADRD caregivers.

Eligibility
• Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
• Applications from Foreign Organizations: Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.

Funding
• Application budgets are not limited but need to reflect the actual needs of the proposed project. Applicants requesting USD $500,000 or more in direct costs in any year (excluding consortium F&A) must contact a Scientific/Research Contact at the NIH at least 6 weeks before submitting the application.
• The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Please see the Funding Opportunity Announcement for further information. Applications may be prepared and submitted via the NIH ASSIST system or Grants.gov. For complete instructions, you must refer to both the NIH Application Guide and the Funding Opportunity Announcement (FOA), noting that instructions in the FOA take precedence over the Application Guide.

Key Dates
Open Date (Earliest Submission Date): 11 February 2019
Applications due to UQ R&I: 25 February 2019
Applications close with NIH: 11 March 2019, 5:00pm local time of applicant organisation
Future application closing dates: 9 July 2019, 12 November 2019, 11 March 2020, 9 July 2020, 12 November 2020, 11 March 2021, 9 July 2021 and 12 November 2021
Expiration date of FOA: 13 November 2021

Ahead of internal review, ensure all online components on ASSIST or Grants.gov are complete. To initiate review, email your completed Funding Application Coversheet to internationalgrants@research.uq.edu.au. Interested applicants are strongly encouraged to make contact with the UQ R&I international team (via internationalgrants@research.uq.edu.au) well in advance of the UQ R&I internal deadline to discuss their application.
Website: http://grants.nih.gov/grants/guide/pa-files/PAR-19-070.html

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