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US National Institutes of Health – Prevention Research in Mid-Life Adults (R21 Clinical Trial Optional) – PA-18-850
Sponsor: US National Institutes of Health 		Closing Date: 16-Feb-2019
This Funding Opportunity Announcement (FOA) seeks to stimulate research on mid-life adults (those 50 to 64 years of age) that can inform efforts to optimize health and well-being as individuals age and prevent illness and disability in later years. The R21 Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects.

The goal of this FOA is to 1) Identify the unique characteristics of mid-life adults that impact health and well-being and contribute to the prevention of disease and disability; 2) Identify characteristics, influences, and indicators that are important for optimal health in mid-life adults; and 3) Develop strategies that promote health and well-being and prevent illness in this population.

Research projects of interest include, but are not limited to, those that:
- Identify risk and protective factors (genetic, behavioral, lifestyle, environmental, sociodemographic) during mid-life that promote health and well-being;
- Determine barriers to effective strategies to prevent illness in disadvantaged mid-life populations;
- Describe patterns of early indicators of disease and disability in mid-life adults and the sequence of preventive strategies that provide maximum benefit;
- Elucidate how age-related perturbations in the microbiome influence biological processes that predispose mid-life adults to chronic illness; develop and test interventions that shift the microbiome toward a protective state;
- Elucidate or leverage motivational factors that promote health and well-being in mid-life adults;
- Determine how mid-life status moderates or mediates the link between multiple responsibilities and health related biological risk;
- Develop interventions tailored to the unique challenges faced by mid-life adults that can reverse early signs and symptoms of chronic disease.

This FOA is intended to encourage clinical studies only (including experimental, observational, or interventional studies in humans); it is not intended for studies in animal models. Studies that include pharmacological agents, herbal medicines, dietary supplements, and probiotics are not appropriate for this FOA. Acupuncture and certain other complementary and alternative interventions are also not appropriate.

Eligibility
• Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
• Applications from Foreign Organizations: Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.

Funding
• The combined budget for direct costs for the two year project period may not exceed USD $275,000. No more than USD $200,000 in direct costs may be requested in any single year.
• The project period may not exceed 2 years.

Please see the Funding Opportunity Announcement for further information. Applications may be prepared and submitted via the NIH ASSIST system or Grants.gov. For complete instructions, you must refer to both the NIH Application Guide and the Funding Opportunity Announcement (FOA), noting that instructions in the FOA take precedence over the Application Guide.

Key Dates
Letter of Intent: Not Applicable
Applications due to UQ R&I: 4 February 2019
Applications close with NIH: 16 February 2019, 5:00pm local time of applicant organisation
Future application closing dates: Standard dates apply until expiry
Expiration date of FOA: 8 September 2021

Ahead of internal review, ensure all online components on ASSIST or Grants.gov are complete. To initiate review, email your completed Funding Application Coversheet to internationalgrants@research.uq.edu.au. Interested applicants are strongly encouraged to make contact with the UQ R&I international team (via internationalgrants@research.uq.edu.au) well in advance of the UQ R&I internal deadline to discuss their application.
Website: http://grants.nih.gov/grants/guide/pa-files/PA-18-850.html

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