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Alpha-1 Foundation – Grants Award Program - Letter of Intent
Sponsor: Alpha-1 Foundation 		Closing Date: 28-Sep-2018
The specific aims of the Grants Award Program are to promote research that would eventually result in the improved health of individuals with Alpha-1 Antitrypsin Deficiency. The Program supports basic science and clinical research, improved understanding of the pathogenesis of the clinical manifestations of AAT Deficiency, the development and testing of treatments for the disease, bioethics and social research, and the promotion of education of members of the medical community regarding AAT Deficiency.

To achieve these aims, the Foundation offers financial awards to support a wide range of meritorious research related to AAT Deficiency including basic laboratory investigations, epidemiology, clinical genetics, clinical trials, clinical management, ethical, legal, and social issues, and public education.

The first step in the process of a grant application to the Alpha-1 Foundation is to submit a Letter of Intent (LOI). The submission of an LOI is required for each grant category. An applicant must submit an LOI in order to submit a grant application.

Eligibility
Topics deemed to be suitable for funding are determined by the Alpha-1 Foundation’s Medical and Scientific Advisory Committee in collaboration with various Foundation working groups and other scientific committees and lay leaders. The Foundation’s current research agenda is available at https://www.alpha1.org/Investigators/Grants/Agenda.

• Pilot and Feasibility Grant
- The objective of this grant is to provide funds to encourage the development and testing of new hypotheses and/or new methods in research areas relevant to AAT Deficiency.
- Proposed work must be hypothesis generating or hypothesis testing, reflecting innovative approaches to important questions in AAT research or development of novel methods, and providing sufficient preliminary data to justify the Foundation’s support.
- Results from Pilot and Feasibility Grants should lead to the submission of applications for funding from other agencies (i.e. NIH). At the conclusion of the funding term, applicants are expected to apply for further funding by other mechanisms or from outside agencies.
- The award is not intended to support continuation of programs begun under other granting mechanisms
• Postdoctoral Research Fellowship Grant
- The objective of this grant is to provide support for postdoctoral research fellows who are starting their research careers and are working in the laboratories of established researchers or conducting research with the mentorship of established researchers.
- Applications will be accepted from candidates holding an M.D., Ph.D. or equivalent degrees who are interested in conducting basic science, clinical research, or ethic, legal, social issues studies related to AAT Deficiency.
- Applicants must indicate a commitment to AAT-related research by focusing 50% of their time to AAT Deficiency research or clinical practice.
• Research Grant
- The objective of this grant is to provide funds to encourage the development of new information that contributes to the understanding of the basic biology of AAT expression, and the pathogenesis/management of AAT Deficiency.
- All proposals must be hypothesis generating or hypothesis testing and provide sufficient preliminary data to justify the Alpha-1 Foundation’s support.

Funding
• The duration of the Alpha-1 Foundation Pilot and Feasibility Grant is 1 year, with funding up to $75,000.
• The duration of the Alpha-1 Foundation Postdoctoral Research Fellowship Grant is 2 years, with funding up to $75,000/year.
• The duration of the Alpha-1 Foundation Research Grant is 2 years, with funding up to $100,000/year.

Please see Alpha1.org. for further information, noting applicants must create a profile and be logged in to the ProposalCentral in order to access the Alpha-1 Foundation’s LOI form. For detailed instructions on preparing the LOI application, please download the Alpha-1 Foundation’s LOI Application Instructions.

Key Dates
Letters of Intent due to UQR&I: 14 September 2018
Letters of Intent close with Alpha-1: 28 September 2018, 11:59pm ET
Invited Full Applications close with Alpha-1: 15 February 2019

For UQR&I internal review and feedback, email your application and completed Funding Application Coversheet to your UQR&I Office of Sponsored Research RAO.
Website: http://www.alpha1.org/Investigators/Grants/Grant-Opportunities

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