Associate Professor
Room 3-341, Steele Building, The University of Queensland, Brisbane, Australia, 4072.
Phone: 07-336-53194
Fax: 07-336-51688
Email: b.charles@pharmacy.uq.edu.au
See also Research Profile
Bruce Charles has an appointment as Reader in the School of Pharmacy. He joined the University in 1988 following 10 years as Senior Scientist in the Department of Clinical Pharmacology, Princess Alexandra Hospital and two years as a Harkness Fellow at the University of Iowa (USA). In recent years he has had a major role in the development of new courses in pharmacotherapeutics. He currently teaches in all years of the BPharm course and the Postgraduate Diploma in Clincal Pharmacy, and has supervised numerous PhD, MPharm and BPharm honours students.
Bruce is involved in research with the Mater Mothers' Hospital and the Mater Children's Hospital. In 2001 purpose-built laboratories iwere open to facilitate this research at the Mater Children's Hospital, South Brisbane.
Research interests
His research encompasses many areas of human and veterinary pharmacotherapeutics, especially population modelling approaches to studying pharmacokinetics in very premature neonates and older children. An example is his recent research funded by the NHMRC which has led to caffeine being adopted as the drug of first choice in the treatment of apnoea of prematurity in Australian hospitals.
Related links
PCalc Software
Specific projects currently underway
Pharmacokinetics and pharmacodynamics of insulin in unstable paediatric diabetes
Toxicokinetics of anthracycline cyctotoxic drugs in children with cancer
Absolute bioavailability of drugs in extremely premature babies
Circadian rhythm of natural hormones in very low birth weight infants
Recent publications
Redmann S, Wainwright C, Stacey S, Champion A, Mitchell P, Cheney J, Charles B. Misleading high tobramycin plasma concentrations can be caused by skin contamination of fingerprick blood following inhalation of nebulised tobramycin (TOBI®). Ther Drug Monit, 27, 205-207, 2005.
Edstein MD, Kocisko DA, Walsh DA, Eamsila C, Charles BG, Rieckmann KH. Plasma concentrations of tafenoquine, a new long-acting antimalarial agent, in Thai soldiers receiving monthly prophylaxis. Clin Infect Dis 37, 1654-1658, 2003.
Hague WM, Davoren PM, McIntyre HD, Norris R, Xiaonian X, Charles B. Metformin crosses the placenta: a modulator for fetal insulin resistance? Br Med J, 327, 880-881, 2003.
Steer PA, Flenady VJ, Charles BG, Gray PG, Henderson-Smart D, Bury G, Fraser S, Hegarty J, Rogers Y, Reid S, Horton L, Charlton M, Jaclin R, Walsh A. High dose caffeine citrate for extubation of preterm infants:A randomised controlled trial. Arch Dis Child (Fetal Neonatal Ed), 89, F499-F503, 2004 .