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Publications arising out of the Program Grant
2012
Vetter I, Mozar CA, Durek T, Wingerd JS, Alewood PF, Christie MJ, Lewis RJ. (2012) Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochem Pharmacol 2012 March3
Lewis RJ, Dutertre S, Vetter I, Christie MJ. (2012) Conus Venom Peptide Pharmacology. Pharmacol Rev 2012 Mar 8
Lewis RJ (2012) Discovery and development of the χ-conopeptide class of analgesic peptides Toxicon 59(4), 524-8
Franco, A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Mari F (2012) RegIIA: an alpha4/7-conotoxin from the venom of Conus regius that potently blocks alpha3beta4 nAChRs Biochem Pharmacol 83(3) 419-26
Napier, I.A., Klimis, H., Rycroft, B.K., Jin, A.H., Alewood, P.F., Motin, L., Adams, D.J., Christie, M.J. (2012) Intrathecal alphaconotoxins Vc1.1, AubIB and MII acting on istinct nicotinic receptor subtypes reverse signs of neuropathic pain Neuropharmacology 62, 2201-2206
Adams, D.J., Callaghan, B., Berecki, G. (2012) Analgesic conotoxins: block and G-protein-coupled receptor modulation of N-type (Cav2.2) calcium channels Bristish Journal of Pharmacology doi: 10.1111/j.1476-5381.2011.01781.x
Knapp, O., Nevin, S.T., Yasuda, T., Lawrence, N., Lewis, R.J., Adams, D.J. (2012) Identification of Nav1.8 channel domain responsible for µO-conotoxin MrVIB binding and biophysical properties of Nav chimeras British Journal of Pharmacology doi: 10.1111/j.1476-5381.2012.01955.x
Dang, V.C., Chieng, B., Azriel, Y., Christie, M.J. (2011) Cellular morphine tolerance produced by betaarrestin-2-deoendent impairment of µ-opioid receptor resensiization J Neuroscience 31(19), 7122-30
Klimis, H., Adams, D.J., Callaghan, B., Nevin, S.T., Alewood, P.F., Vaughan, C.W., Mozar, C.A. and Christie, M.J. (2011) A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain Pain 152, 259-266
Inserra MC, Lewis RJ (2011) Venom peptide modulators of the immune system Inflamm Allergy Drug Targets 10(5) 399-410
Muttenthaler M., Akondi KB, Alewood PF (2011) Structure-activity studies on alpha-conotoxins Curr Pharm Des 17(38) 4226-41
de Araujo AD, Callaghan B., Nevin ST, Daly NL, Craik DJ, Moretta M, Hopping G, Christie MJ, Adams DJ, Alewood PF (2011) Total synthesis of the analgesic conotoxin MrVIB through selenocyseine-assisted folding Angew Chem Int Ed Engl 50(29): 6527-9
Adams, DJ, Callaghan B., Berecki G. (2011) Analgesic conotoxins: Block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels Br J Pharmacol 166 486-500
Berecki, G., Motin, L., Haythornthwaite, A., Vink, S., Bansal, P., Drinkwater, R., Wang, C.I., Moretta. M., Lewis, R.J., Alewood, P.F., Christie, M.J. and Adams, D.J. (2010) Analgesic omega-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinent and native N-type calcium channels Molecular Pharmacology 77(2): 139-148
Callaghan, B. and Adams, D.J. (2010) Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurones of alpha 9 nicotinic receptor knockout mice Channels 4(1): 51-54
Dutertre, S., Lewis RJ. (2010) Use of venom peptides too probe ion channel structure and function J Biol Chem 285(18) 13315-20
Grishin, A.A., Wang, C.I.A., Muttenthaler, M., Alewood, P.F., Lewis, R.J. and Adams, D.J. (2010) alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha 3 beta 4 nicotinic acetylcholine receptors Journal of Biological Chemistry 285(29): 22254-22263
Ittner, L.M., Ke, Y.D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B.C., Christie, M.J., Napier, I.A., Eckert, A., Staufenbiel, M., Hardeman, E., Götz, J. (2010) Tau mediates Amyloid-Toxicity in Alzheimer's Disease mouse models by interaction with Fyn Cell 142:387-97
Luo, S.L., Akondi, K.B., Zhangsun, D.T., Wu, Y., Zhu, X.P., Hu, Y.Y., Christensen, S., Dowell, C., Daly, N.L., Craik, D.J., Wang, C.I.A., Lewis, R.J., Alewood, P.F. and McIntosh, J.M. (2010) Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha 3 beta 2 nicotinic receptor Journal of Biological Chemistry 285(16): 12355-12366
Morales, R.A.V., Daly, N.L., Vetter, I., Mobli, M., Napier, I.A., Craik, D.J., Lewis, R.J., Christie, M.J., King, G.F., Alewood, P.F., and Durek, T. (2010) Chemical synthesis and structure of the prokinetcin Bv8 Chembiochem 11:1882-1888
Muttenthaler, M., Andersson, Å., de Araujo, A.D., Dekan, Z., Lewis, R.J., Alewood, P.F. (2010) Modulating oxytocin activity and plasma stabiity by disulfide bond engineering J Med Chem 24: 8585-8596
Muttenthaler, M., Nevin, S.T., Grishin, A.A., Ngo, S.T., Choy P.T., Daly, N., Hu, S-H., Armishaw, C.J., Wang, C.I.A., Lewis, R.J., Martin, J.L., Noakes, P.G., Craik, D.J., Adams. D.J., and Alewood, P.F. (2010) Solving the alpha-conotoxin folding problem: selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists Journal of the American Chemistry Society 132(10): 3514-3522
Brust, A., Palant, E., Croker, D.E., Colless, B., Drinkwater, R., Patterson, B., Schroeder, C.I., Wilson, D., Nielsen, C.K., Smith, M.T., Alewood, D., Alewood, P.F. and Lewis, R.J. (2009) Chi-conopeptides pharmacophore development: Towards a novel class of Norepinephrine Transporter Inhibitor (Xen2174) for pain (Xen2174) for pain Journal of Medicinal Chemistry 52(22): 6991-7002
Christie, M.J. & Mallet, C. (2009) Endocannabinoids can open the pain gate Science Signaling 2(88): 57
Dang, V.C., Napier, I.A. & Christie, M.J. (2009) Two distinct mechanisms mediate acute micro-opioid receptor desensitization in native neurons Journal of Neuroscience 29(10): 3322-3327
Davis, J., Jones, A. & Lewis, R.J. (2009) Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS Peptides 30(7): 1222-1227
Halai, R., Clark, R.J., Nevin, S.T., Jensen, J.E., Adams, D.J. and Craik, D.J. (2009) Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha 9 alpha 10 nicotinic acetylcholine receptorJournal of Biological Chemistry 284(30): 20275-20284
Hopping, G., Lewis, R.J. and Alewood, P.F. (2009) Rapid access to w-conotoxin chimeras using native chemical ligation Australian Journal of Chemistry 62(10): 1333-1338
Jensen, J.E., Durek, T., Alewood, P.F., Adams, D.J., King, G.F. and Rash, L.D. (2009) Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Toxicon 54(1): 56-61
Lewis, R.J. (2009) Conotoxin venom peptide therapeutics Advanced Experimental Medical Biology 655: 44-48
Lewis, R.J. (2009) Conotoxins: molecular and therapeutic targets Marine Molecular Biotechnology 46: 45-65
Loughnan, M.L., Nicke, A., Lawrence, N & Lewis, R.J. (2009) Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily Biochemistry 48(17): 3717-3729
Millard, E.L., Nevin, S.T., Loughnan, M.L., Nicke, A.C., Clark, R.J., Alewood, P.F., Lewis, R.J., Adams, D.J., Craik, D.J. and Daly, .L. (2009) Inhibition of neuronal nicotinic acetylchlorine receptor subtyprs by alpha conotoxin GID and analogues Journal of Biological Chemistry 284(8): 4944-4952
Ueberheide, B.M., Fenyo, D., Alewood, P.F and Chait, B.T. (2009) Rapid sensitive analysis of cysteine rich peptide venom components Proceedings of the National Acadamy of Science (USA) 106(17): 6910-6915
Callaghan, B., Haythornthwaite, A., Berecki, G., Clark, R.J., Craik, D.J. and Adams, D.J. (2008) Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA(B) receptor activation Journal of Neuroscience 28(43): 10943-10951
Christie, M.J. (2008) Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction British Journal of Pharmacology 154(2): 384-396
Dutertre, S., Croker, D., Daly, N.L., Andersson, Å., Muttenthaler, M., Lumsden, N.G., Craik, D.J., Alewood, P.F., Guillon, G. and Lewis, R.J. (2008) Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides Journal of Biological Chemistry 283(11): 7100-7108
Ekberg, J., Craik, D.J. and Adams, D.J. (2008) Conotoxin modulation of voltage-gated sodium channels International Journal of Biochemistry and Cell Biology 40(11): 2363-2368
Jin, A-H, Daly, N.L., Nevin, S.T., Wang, C.I.A., Dutertre, S., Lewis, R.J., Craik, D.J. and Alewood, P.F. (2008) Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function Journal of Medicinal Chemistry 51(18): 5575-5584
Motin, L. and Adams, D.J. (2008) omega-conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn Neuropharmacology 55(5): 860-864
Schroeder, C.I., Ekberg, J., Nielsen, K.J., Adams, D., Loughnan, M.L., Thomas, L., Adams, D.J., Alewood, P.F. & Lewis, R.J. (2008) Neuonally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels Journal of Biological Chemistry 283(31): 21621-28628
Schroeder, C.I., Ekberg, J., Nielsen, K.J., Adams, D., Lougnan, M., Thomas, L., Adams, D.J., Alewood, P.F. and Lewis, R.J. (2008) Neuronally selective mu-conotoxins from Conus striatius utilize an alpha-helical motif to target mammalian sodium channels Journal of Biological Chemistry 283(31): 21621-21628
Vikman, K.S., Rycroft, B.K. & Christie, M.J. (2008) Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the ratJournal of Physiology – London 586(2): 515-527
2007
Blanchfield, J.T., Gallagher, O.P., Cros, C., Lewis, R.J., Alewood, P.F. and Toth, I. (2007) Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue Biochemical and Biophysical Research Communications 361(1): 97-102
Craik, D.J. and Adams, D.J. (2007) Chemical modification of conotoxins to improve stability and activity ACS Chemical Biology 2(7): 457-468
Dekan, Z., Paczkowski, F., Lewis, R. and Alewood P. (2007) Synthesis and In vitro biological activity of Cyclic Lipophilic chi-Conotoxin MrIA analogues International Journal of Peptide Research and Therapeutics 13(1-2): 307-312
Dutertre, S., Ulens, C., Buttner, R., Fish, A., van Elk, R., Kendel, Y., Hopping, G., Alewood, P.F., Schroeder, C., Nicke, A., Smit, A.B., Sixma, T.K., and Lewis, R.J. (2007) AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtyoe selectivity EMBO Journal 26(16): 3858-3867
Jin, A., Brandstaetter, H., Nevin, S.T., Tan, C.C., Clark, R.J., Adams, D.J., Alewood, P.F., Craik, D.J. and Daly, N.L. (2007) Structure of alpha-conotoxin BuIA: Influences of disulphide connectivity on structural dynamics BMC Structural Biology 7: 28
Lewis, R.J., Schroeder, C.I., Ekberg, J., Nielsen, K.J., Loughnan, M., Thomas, L., Adams, D.A., Drinkwater, R., Adams, D.J. and Alewood, P.F. (2007) Isolation and structure activity of mu-conotoxin TIIIA. A potent inhibitor of Tetrodotoxin-Sensitive Votage-Gated Sodium Channels Molecular Pharmacology 71(3): 676-685
Liu, X., Banister, S.D., Christie, M.J., Banati, R., Meikle, S., Coster, M.J. & Kassiou, M (2007) Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects European Journal of Pharmacology 555(1): 37-42
Motin, L., Yasuda, T., Schroeder, C.I., Lewis R.J. and Adams, D.J. (2007) omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels European Journal of Neuroscience 25(2): 435-444
Nevin, S.T., Clark, R.J., Klimis, H., Christie, M.J., Craik, D.J. and Adams, D.J. (2007) Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology 72(6): 1406-1410
Paczkpwski, F.A., Sharpe, I.A., Dutertre, S. & Lewis, R.J (2007) chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model Journal of Biological Chemistry 282(24): 17837-17844
Rycroft, B.K., Vikman, K.S. & Christie, M.J. (2007) Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina 1 neurons in the rat dorsal hornJournal of Physiology – London 580(3): 883-894
Yasuda, T. and Adams, D.J. (2007) Voltage-gated calcium channels in nociception In: Sensing with Ion Channels. Edited by B. Martinac, Springer, Heidelberg Chapter 13: 267-298
2006
Armishaw, C.J., Daly, N., Nevin, S., Adams, D.J., Craik, D.J. and Alewood, P.F. (2006) Alpha-selenoconotoxins: A new class of potent alpha 7 neurinal nicotinic receptor antagonists Journal of Biological Chemistry 281(20): 14136-14143
Christie, M.J. (2006) Opioid and cannabinoid receptors: friends with benefits or just close friends? British Journal of Pharmacology 148(4): 385-386
Dutertre, S. & Lewis, R.L. (2006) Toxin insights into nicotinic acetylcholine receptors Biochemical Pharmacology 72(6): 661-670
Dutertre, S., Lumsden, N., Alewood, P. and Lewis, R. (2006) Isolation and characterization of Conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail FEBS Letters 580(16): 3860-3866
Ekberg, J. and Adams, D.J. (2006) Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain International Journal of Biochemistry and Cell Biology 38(12): 2005-2010
Ekberg, J., Jayamanne, A., Vaughan, C.W., Aslan, S., Thomas, L., Mouldt, J., Drinkwater, R., Baker, M.D., Abrahamsen, B., Wood, J.N., Adams, D.J., Christie, M.J. and Lewis, R.J. (2006) mO-conotoxin MrVIB selectively blocks NaV1.8 sensory neuron specific sodium channels and chronic pain behaviour without motor deficits Proceedings of the National Acadamy of Science (USA) 103(45): 17030-17035
Jennings, E.A., Christie, M.J. & Sessle, B.J. (2006) ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis Neuroreport 17(14): 1507-1510
Loughnan, M., Nicke, A., Jones, A., Schroeder, C., Nevin,. S., Adams, D., Alewood, P.F. and Lewis, R.J. (2006) Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxVIIB and VxXIIC from Conus vexillum Journal of Biological Chemistry 281(34): 24745-24755
Loughnan, M., Nicke, A., Jones, A., Schroeder, C.I., Nevin, S.T., Adams, D.J., Alewood, P.F. & Lewis, R.J (2006) Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum Journal of Biological Chemistry 281(34): 24745-24755
Lovelace, E.S., Armishaw, C.J., Colgrave, M.L., Wahlstrom, M.E., Alewood, P.F., Daly, N.L. and Craik, D.J. (2006) Cyclic MrIA: A stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter Journal of Medicinal Chemistry 49(22): 656-6568
Schroeder, C.I., Doering, C.J., Zamponi, G.W. & Lewis, R.J. (2006) N-type calcium channel blockers: novel therapeutics for the treatment of pain Journal of Medicinal Chemistry 2(5): 535-543
2005
Wen, S., Wilson, D., Kurruppu, S., Korsonczky, M., Hendrick, J., Pang, L., Szeto, T., Hodgson, W., Alewood, P and Nicholson, G. (2005) Discovery of an MIT-like atracotoxin family: spider venom polypeptides that share sequence homology but not pharmacological properties with AVIT family proteins. Peptides 26(12): 2412-2426
Armishaw, C.J. and Alewood, P.F. (2005) Conotoxins as Research Tools and Drug Leads Current Protein and Peptide Science 6(3): 221-240
Bagley, E.E., Chieng, B.C., Christie, M.J. & Connor, M. (2005) Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine British Journal of Pharmacology 146(1): 68-76
Bagley, E.E., Gerke, M.B., Vaughan, C.W., Hack, S.P., Chrisite, M.J. (2005) GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal Neuron 45(3): 433-445
Chieng, B.C.H., Hallberg, C., Nyberg, F.J. & Christie, M.J. (2005) Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal Neuroreport 16(12): 1279-1283
Hack, S.P., Bagley, E.E., Chieng, B.C.H. & Christie, M.J. (2005) Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment Journal of Neuroscience 25(12): 3192-3198
Hall, W., Christie, M.J. & Currow, D. (2005) Cannabinoids and cancer: causation, remediation and palliation Lancet Oncology 6(1): 35-42
Johnson, E.E., Christie, M.J. and Connor, M. (2005) The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment NeuroSignals 14(6): 290-302
Liu, X., Mattner, F., Katsifis, A., Christie, M.J. & Kassiou, M. (2005) Influence of Trishomocubanes on Sigma Receptor binding of N-(1-Benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain Journal of Medicinal Chemistry 1(1): 31-38
Marinelli, S., Connor, M., Schnell, S.A., Christie, M.J., Wessendorf, M.W. & Vaughan, C.W. (2005) Delta-opioid receptor-mediated actions on rostral ventromedial medulla neurons Neuroscience 132(2): 239-244
Nilsson, K.R., Lovelace, E., Caesar, C., Tynngard, N., Alewood, P.F., Johansson, H., Sharpe, I.A., Lewis, R., Daley, N., and Craik, D. (2005) Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter Bioploymers (Peptide Science) 80(6): 815-823
All publications by the Chief Investigators (click to get PubMed link, then remove Limits) :