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Publications arising out of the Program Grant
Jasmine Davis, Alun Jones, Richard J. Lewis, (2009) Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS Peptides , 30(7),1222-1227
Lewis RJ. (2009) Conotoxins: molecular and therapeutic targets. Prog Mol Subcell Biol. ;46:45-65. Review.
Jensen, J.E., Durek, T., Alewood, P.F., Adams, D.J., King, G.F. and Rash, L.D. (2009). Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. Toxicon (In press; doi:10.1016/j.toxicon.2009.03.014)
Halai, R., Clark, R.J., Nevin, S.T., Jensen, J.E., Adams, D.J. and Craik, D.J. (2009). Scanning mutagenesis of a-conotoxin Vc1.1 reveals residues crucial for activity at the a9a10 nicotinic acetylcholine receptor. Journal of Biological Chemistry (In press; doi/10.1074/jbc.M109.015339)
Loughnan ML, Nicke A, Lawrence N, Lewis RJ. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily.
Biochemistry. May 5;48(17):3717-29.
Vu C. Dang, Ian A. Napier,and MacDonald J. Christie (2009) Two Distinct Mechanisms Mediate Acute mu-Opioid Receptor Desensitization in Native Neurons , The Journal of Neuroscience, 29(10):3322–3327
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. (2009) Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. Feb 20;284(8):4944-51. Epub 2008 Dec 19.
2008
Jin, AH, Daly, NL, Nevin, ST, Wang, CI, Dutertre, S, Lewis RJ, Adams, DJ, Craik, DJ and Alewood, PF (2008) Molecular engineering of conotoxins: the importance of loop size to α-conotoxin structure and function. J Med Chem 51:5575-5584.
Motin, L. and Adams, DJ, ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology (2008),
doi:10.1016/j.neuropharm.2008.06.049 Ekberg, J, Craik, DJ. and Adams, DJ. Conotoxin modulation of voltage-gated sodium channels. International Journal of Biochemistry & Cell Biology 40, 2363 - 8, (2008)
Vikman KS, Rycroft BK, Christie MJ. Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat. J Physiol. (Lond.), 586:515-27,(2008)
Christie MJ Cellular neuroadaptations to chronic opioids: Tolerance, withdrawal and addiction. Brit J Pharmacol 154(2), 384-96 (2008)
Sébastien Dutertre, Daniel Croker, Norelle L. Daly, Åsa Andersson, Markus Muttenthaler, Natalie G. Lumdsen, David J. Craik, Paul F. Alewood, Gilles Guillon and Richard J. Lewis. Conopressin-T from Conus Tulipa reveals an antagonist switch in vasopressin-like peptides. J Biol Chem 283, 7100-7108, 2008.
Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan M, Thomas L, Adams DJ, Alewood PF and Lewis RJ, Neuronally selective μ-conotoxins from Conus striatus utlise an α-helical motif to target mammalian sodium channels. J Biol Chem 283(31), 21621-8 (2008)
M Muttenthaler and PF Alewood. Selenocystine Peptides - Synthesis, Folding and Applications in "Oxidative Folding of Proteins and Peptides" Eds (Luis Moroder and Johannes Buchner) Royal Chemical Society, 2008. Invited contribution
M Muttenthaler and PF Alewood. Synthesis of Selenopeptides. J Pept Science. Invited contribution (submitted June 2008)
Christie MJ, Tolerance and Dependence. In: Binder, M, Nobutaka Hirokawa, N, Hirsch, M. (Marburg Germany). (Eds) Encyclopedia of Neuroscience, Springer, Heidelberg (in press). (2008)
2007
Craik, DJ and Adams, DJ, Chemical modifications of conotoxins to improve stability and activity. ACS Chemical Biology, 2007, 2(7), 457-468
Yasuda, T. and Adams, D.J. (2007). Voltage-gated calcium channels in nociception. In: Sensing with Ion Channels. Edited by B. Martinac, Springer, Heidelberg. Chapt. 13, pp. 267-298.
Paczkowski FA, Sharpe IA, Dutertre S, Lewis RJ. chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.J Biol Chem. 2007 Jun 15;282(24):17837-44.
Rycroft BK, Vikman KS, Christie MJ Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor positive lamina I neurons in the rat dorsal horn. J Physiol. 2007 Feb 15; [Epub ahead of print]
Motin, L, Yasuda, T., Schroeder, CI, Lewis, RJ and Adams DJ, ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q type calcium channels, Eur J. Neurosci. 2007, 25, 435-444
Lewis, RJ, Schroeder, CI, Ekberg, J, Nielsen,KJ, Loughnan, M, Thomas, L, Adams, D, Drinkwater, R, Adams, DJ and Alewood, PF. Isolation and structure-activity of mu-conotoxin TIIIA. A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels..Mol Pharmacol. Mar;71(3):676-85, 2007.
2006
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ. uO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A. 2006 Oct 31; [Epub ahead of print]
Schroeder CI, Doering CJ, Zamponi GW, Lewis RJ. N-type calcium channel blockers: novel therapeutics for the treatment of pain. Med Chem. 2006 Sep;2(5):535-43.
Sébastien Dutertre, Natalie Lumsden, Paul F. Alewood and Richard J. Lewis (2006) Isolation and characterisation of Conomap-Vt, a D-amino acid containing excitatory peptide from Conus vitulinus venom , FEBS Lett. 2006 Jul 10;580(16):3860-6. Epub 2006 Jun 16.
Ekberg, J and Adams DJ, (2006) , Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain, Int J. of Biochemistry and Cell Biology, 38, 2005-10
All publications by the Chief Investigators (click to get PubMed link, then remove Limits) :
RJ Lewis
PF Alewood
DJ Adams
MJ Christie