Dissecting Pain Pathways using
Venom Peptides
      


 Our Researchers


The success of any Program grant is reliant on good staff who can work collaboratively and share ideas. The Chief Investigators have many years of collaborative work between them. This page is to introduce emerging researchers who are playing an integral part in the success of this program.

 

 
 

Name

From 

Education & Experience

Recent Publications (as first author)

Simon Nevin

2005 - PhD:  
Lachlan Rash 2005 -

PhD:

 
Geza Berecki 2007 -

Ph.D: Faculty of Mathematics and Natural Sciences, University of Leiden, the Netherlands (2001)

Appointments: RO - Queensland Brain Institute- current, University of Amsterdam, The Netherlands (2002-6)

Awards: 2002: Marie Curie Fellowship from the European Union
2006:  Postdoctoral fellowship from the University of Queensland

Berecki G, Zegers JG, Wilders R, Van Ginneken AC.Cardiac channelopathies studied with the dynamic action potential clamp technique. 2007. Methods Mol Biol. 403:233-250
Berecki G., Den Ruijter H.M., Verkerk A. O., Schumacher CA, Baartscheer A., Bakker D., Boukens B.J., van  Ginneken A.C., Fiolet J.W., Opthof T., Coronel R. 2007. Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes. Heart Rhythm J. 4:1452-1460
Berecki G., Zegers J.G., Bhuiyan Z.A., Verkerk A.O., Wilders R., van Ginneken A.C.G. 2006. Long QT syndrome-related sodium channel mutations probed by dynamic action potential clamp technique. J Physiol. 570:237–250
 
Anton Grishin 2006 - PhD:  
Aline Dantas de Araujo 2006 - PhD:  
Thomas Durek 2008 -

PhD: Chemistry, Max-Planck-Institute for Molecular Physiology, Dortmund, Germany

Appointments: IMB, Uni of Qld - current, University of Chicago, USA (2005-6)

Awards: Wyeth Award of the Biomedical Society Dortmund (2004)

Durek T, Alexandrov K, Goody RS, Hildebrand A, Heinemann I, Waldmann H. Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. Journal of the American Chemical Society (2004) 126, 16368-16378
Durek T, Becker CF. Protein semi-synthesis: new proteins for functional and structural studies. Biomolecular Engineering (2005) 22, 153-172
Durek T, Torbeev VY, Kent SB. Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme. Proceedings of the National Academy of Sciences, USA (2007) 104, 4846-4851
 
Aihua Jin 2008 -

PhD: Molecular Bioscience, University of Queensland (2006)

Appointments: IMB, Uni of Qld - current

Jin, A.H., Daly, N.L., Nevin, S.T., Lewis, R.J., Adams, D.J., Craik, D.J., and Alewood, P.F. Molecular engineering of conotoxins: the importance of loop size to a-conotoxins structure and function. Journal of Medicinal Chemistry, 2008 Sep 25; 51 (18): 5575-84.
Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL. Structure of alpha-conotoxin BuIA: Influences of disulfide connectivity on structural dynamics. BMC Structural Biology, 2007 Apr 20;7(1):28.
Marion Loughnan 2009 -

PhD: University of Queensland (2007), M. Rur Sci., UNE

Appointments: IMB, Uni of Qld - current, Centre for Drug Design & Development (UQ)

Awards: APA for PhD funding, Dean’s Commendation for PhD thesis

Loughnan, M.L., Nicke, A., Lawrence, N. and Lewis. R.J. (2009) “Novel αD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily” Biochemistry In Press (Accepted manuscript)
Loughnan, M., Nicke, A., Jones, A., Schroeder, C.I., Nevin, S.T., Adams, D.J., Alewood, D.F. and Lewis, R.J. (2006) “Identification of a novel class of nicotinic receptor antagonists: Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum”. Journal of Biological Chemistry 281 (34) 24745-24755
Loughnan, M.L. and Alewood, P.F.A. (2004) “Mini Review: Physico-chemical characterization and synthesis of neuronally active α-conotoxins”. European Journal of Biochemistry 271 (12) 2294-2304
Anderson Wang 2008 -

PhD: School of Molecular and Microbial Sciences
University of Queensland (2007)

Appointments - Institute for Molecular Biosciences, the University of Queensland -current

Awards: UQ joint research scholarship (2005), UQ SMMS scholarship (2004)

Wang, C.I.A., *Guncar, G., Forwood, J.K., Teh, T., Catanazriti, A.M., Lawrence, G.J.,
Schirra, H., Anderson, P., Ellis, J.G., Dodds, P.N. and Kobe, B. (2007). Crystal structure of flax rust avirulence proteins AvrL567-A and AvrL567-D reveal the structure basis for flax disease resistance specificity. Plant Cell 19, 2898-2912
 
Asa Andersson 2007 -

Master of Pharmaceutical Bioscience at Göteborg University, Sweden (2003)

 

 
Lotten Ragnarsson-McGrath 2007 -

PhD: Department of Biochemistry, University of Queensland (2004)

Appointments: RO- IMB, University of Queensland-current
RO- Department of Physiology and Pharmacology, University of Queensland, including 5 months at the University of Calgary, Canada
SRO- Xenome Ltd, Indooroopilly, Qld, Australia

Awards: •    2000 – Awarded University of Queensland International Postgraduate Research Scholarship (UQIPRS).

Ragnarsson L., Yasuda T., Lewis R.J., Dodd P.R. and Adams D.J. (2006) NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G. J Neurochem. 96(1): 283-91.
Ragnarsson L., Mortensen M., Dodd P. R., and Lewis R. (2002) Spermine modulation of the glutamate-NMDA receptor is differentially responsive to conantokins in normal and Alzheimer diseased human cerebral cortex. J.Neurochem. 81(4): 765-79.
Ragnarsson L, Strömberg T, Wijdenes J, Tötterman TH, and Weigelt C. (2001) Multiple myeloma cells are killed by syndecan-1-directed superantigen-activated T cells. Cancer Immunol Immunother. 50(7):382-90.
 
Brid Callaghnan 2006 -

Ph.D: (Cellular and Molecular Pharmacology and Physiology). University of Nevada, Reno, Nevada, 2005.

Appointments: Queensland Brain Institute

Callaghan, B., J. Zhong, and K.D. Keef, Signaling pathway underlying stimulation of L-type Ca2+ channels in rabbit portal vein myocytes by recombinant Gbetagamma subunits. Am J Physiol Heart Circ Physiol, 2006. 291(5): p. H2541-6

B.P. Callaghan, Cobine, C.A., and K.D. Keef, Role of L-type Calcium Channels and PKC in Active Tone Development in Rabbit Coronary Artery. Am J Physiol Heart Circ Physiol, 2007. Jun;292(6):H3079-88
Brid Callaghan, Alison Haythornthwaite, Geza Berecki, Richard J. Clark, David J. Craik, and David J. Adams. Analgesic α-Conotoxins Vc1.1 And Rg1A Inhibit N-Type Calcium Channels In Rat Dorsal Root Ganglion Neurons Via GABAB  Receptor Activation.  In Press J. Neuroscience

Irina Vetter 2008 -
PhD:  School of Pharmacy, University of Queensland (2007)

Appointments: IMB, Uni of Qld-current, Queensland Brain Institute, Axon guidance

Awards:2008 NHMRC Australian Biomedical Training Fellowship
Vetter I*, Pujic Z*, Goodhill GJ. Response of Dorsal Root Ganglion Axons to NGF gradients depends on spinal level. In preparation.
Vetter I, Cheng W, Peiris M, Wyse BD, Roberts-Thomson SJ, Zheng J, Monteith GR, Cabot PJ. Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. J Biol Chem. 2008 Jul 11;283(28):19540-50. (IF 5.58)
Vetter I, Wyse BD, Roberts-Thomson SJ, Monteith GR, Cabot PJ. Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. Eur J Pain. 2008 May;12(4):441-54.  (IF 3.71)
Christine Mozar 2009 - PhD:  
Markus Muttenthaler 2006 -

PhD: University of Queensland -submiited 2008

Appointment: IMB, Uni of Qld -current

Awards:IMB/UQ – Scholarship for PhD program
IPRS (International Postgraduate Research Scholarship) and the UQILAS (University of Queensland International Living Allowance Scholarship) for PhD program

Muttenthaler M and Alewood PF. in Oxidative Folding of Peptides and Proteins, Chapter 8: Selenocystine Peptides - Synthesis, Folding and Applications (eds. Johannes B and Moroder L), Royal Society of Chemistry, Cambridge, 2009.
Muttenthaler M
and Alewood PF. Selenopeptide chemistry. Journal of Peptide Science, 2008; 14, 1223-39.
Muttenthaler M,
Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu S-H, Armishaw CJ, Martin JL, Noakes PG, Craik DJ, Adams DJ and Alewood PF. Solving the folding problem of α−Conotoxins with selenocysteine leads to more potent and stable neuronal nicotinic blockers. Nature Chemical Biology, 2009; submitted.

 

 

 

 

 

 

 

 

 

Former Staff    
        
Melissa Moretta, Thea Monks, Natalie Lumsden, Nira Gamage, Gene Hopping, Beth Rycroft, Aijun Yang, Filip Paczkowski, Alison Haythornthwaite, Christina Schroeder, Paramjit Bansal, Nicole Lawrence, Brooke Purdue