Seminar: West Nile Avian Virulence Determinants
Event Details
- Date:
- Tuesday, 18 September 2012
- Time:
- 3:30 pm - 4:30 pm
- Room:
- Seminar Room
- UQ Location:
- Australian Institute for Bioengineering and Nanotechnology (St Lucia)
- URL:
- http://www.uq.edu.au/aid/seminars
- Event category(s):
Event Contact
- Name:
- Dr Kate Stacey
- Phone:
- 54043
- Email:
- katryn.stacey@uq.edu.au
- Org. Unit:
- Australian Infectious Diseases Research Centre
Event Description
- Full Description:
- This Australian Infectious Diseases Research Centre seminar will be delivered by Aaron C. Brault,
Division of Vector-Borne Infectious Disease, Centers for Disease Control and Prevention, UC Davis
Aaron Brault's research interests focus on the interaction of arthropod-borne viruses (such as West Nile virus (WNV)) with their vertebrate and invertebrate hosts. This task is approached through the development of molecular tools for the identification of virally encoded determinants of vector competence, vertebrate pathogenesis as well as the use of viral expression systems for the identification and intervention of arboviral diseases in mosquitoes. Ongoing research conducted in Aaron's laboratory consists of an eclectic mixture of field biology, entomology, molecular biology and genetics. Current work in Aaron's laboratory has focused on the epidemiology of WNV and the specific identification of virally-encoded virulence determinants that result in increased virulence of WNV in birds. Recent work has combined both positive selection modelling and reverse genetic approaches for the identification of a specific mutation in the viral helicase of WNV associated with epizootic emergence through the increased replication in avian hosts. Studies ongoing in the laboratory are aimed at elucidating the pathophysiological factors leading to virulence such as differential tissue tropism, temperature constraints on viral replication as well as novel mechanisms for the development of live attenuated vaccine constructs.
Directions to UQ
- Google Map:
-
- Directions:
- To St Lucia Campus, UQ Ipswich, and UQ Gatton.
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