Event Details

Date:
Wednesday, 24 July 2019 - Wednesday, 24 July 2019
Time:
11:00 am - 12:00 pm
Room:
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
URL:
http://www.qbi.uq.edu.au/neuroscience-seminars
Event category(s):

Event Contact

Name:
Ms Deirdre Wilson
Phone:
66300
Email:
d.wilson5@uq.edu.au
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Professor Alice Pebay
NHMRC Senior Research Fellow
Department of Surgery, Melbourne Medical School
Department of Anatomy and Neuroscience, School of Biomedical Sciences
The University of Melbourne, VIC

Title: 'Modelling neurodegeneration using patient induced pluripotent stem cells'

Abstract: The difficulty in obtaining tissue from the eye or brain of living people is a major barrier to the understanding and development of new treatments for neurodegenerative diseases. Patient-specific induced pluripotent stem cells (iPSCs) provide a powerful means by which to investigate the pathogenesis of disease, as these cells can be differentiated into relevant cell types of interest for disease modelling, drug screening, and understanding of fundamental biology. Yet, for complex diseases, which involve various genetic and environmental factors, large numbers of samples are necessary to robustly confirm biological effects. To enable large-scale iPSC-disease modelling studies and standardisation of iPSC culture, we have established protocols for automation of stem cell culture that ensure sufficient throughput and standardisation of iPSC culture with minimal variation. Similarly, for monogenic conditions, that are amenable to gene-editing and thus require smaller sample size for disease modelling, we combine CRISPR/Cas9- editing with iPSCs, to generate isogenic iPSCs lines, allowing a robust in vitro model of disease. Both large-scale and gene editing approaches will be illustrated here.

Directions to UQ

Google Map:
Directions:
St Lucia Campus | Gatton campus.

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