Event Details

Monday, 20 August 2018 - Monday, 20 August 2018
3:00 pm - 4:00 pm
Auditorium, room 701, QBi building 79
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Charmaine Paiva
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Professor Jianyuan Sun
State Key Laboratory of Brain & Cognitive Sciences
Institute of Biophysics, Chinese Academy of Sciences

Seminar Title: Quantal transmission at single central synapses displays large variation in size with subunit

In their seminal work, Katz and colleagues established the quantal nature of synaptic transmission, whereby the basic unit of neurotransmission is the quantal event detected postsynaptically as a small all-or-none similar sized miniature postsynaptic potential or current (mini), in response to the neurotransmitter release from a single vesicle. However, the quantal nature of minis has never been justified by the study at single synapses, leaving the open question whether minis are identical in size and follow the principle of invariance. Here, we selectively study the quantal transmission from single active zone contained synapses using whole-cell recording and quantitative analysis. It was found that the amplitude of spontaneous and evoked miniature events from single synapses displayed large variation and could be estimated as integer multiples of a subunit. Our study revealed a large encoding scope of quantal synaptic transmission and the higher capacity of synaptic information processing than that the quantal theory implied.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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