Event Details

Date:
Friday, 18 May 2018
Time:
12:30 pm - 1:30 pm
Room:
QBP Auditorium
UQ Location:
Queensland Bioscience Precinct (St Lucia)
URL:
https://imb.uq.edu.au/event/8822/imb-friday-seminar-series
Event category(s):

Event Contact

Name:
Ms Katrina Garner-Moore
Phone:
3346 2133
Email:
imbevents@uq.edu.au
Org. Unit:
Institute for Molecular Bioscience

Event Description

Full Description:
Dr Jennifer Deuis - The role of ion channels in pain pathways

In Australia, one in five people live with chronic pain, and the prevalence of chronic pain is projected to increase further as Australia’s population ages. In recent years, ion channels have received attention as putative analgesic targets due to their crucial role in the generation of action potentials (electrical signals) in pain-sensing nerves. Our research aims to define the precise role of specific ion channel isoforms in modality- and disease-specific pain pathways to identify novel drug targets

Dr Quan Nguyen - Genetic networks modulating cell fate specification and contributing to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution

To investigate the dynamic changes in gene expression across the cardiac lineage, we generated RNA-sequencing data captured from 43,168 single cells progressing through in vitro cardiac-directed differentiation from pluripotency. We developed two single-cell transcriptomics analysis software, implementing a novel and generalized unsupervised cell clustering approach and a machine learning method for predicting cell transition between clusters. Using these methods, we were able to reconstruct the cell fate choices as cells transition from a pluripotent state to mature cardiomyocytes, uncovering intermediate cell populations that do not progress to maturity, identifying distinct cell trajectories and genes associated to cardiovascular disease risks.

Directions to UQ

Google Map:
Directions:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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