QBI Neuroscience Seminar: 'Cell death in adult hippocampal neurogenesis is ferroptotic and rescued by selenium'

Event Details

Date:

Thursday, 19 April 2018 - Thursday, 19 April 2018

Time:

11:00 am - 12:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Queensland Brain Institute (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Dr Tara L Walker
Senior Research Associate, Kempermann Group,
Center for Regenerative Therapies Dresden, Germany
Title: 'Cell death in adult hippocampal neurogenesis is ferroptotic and rescued by selenium'
Abstract: Apoptotic cell death is a key mechanism controlling the generation of new neurons in the adult hippocampus, a brain region important for learning and memory. We show here that ferroptosis, a recently-discovered form of programmed cell death with as yet unknown physiological functions, explains the first wave of cell death at the precursor cell stage of neurogenesis. Reduction of ferroptosis by exogenous selenium increased neurogenesis in the hippocampus but not the subventricular zone, another adult neural stem cell niche. This suggests a mechanism whereby external stimuli including physical activity increase hippocampal but not subventricular zone neurogenesis. We propose that ferroptotic elimination maintains an expandable reservoir of neural precursor cells that is sensitive to the environmental regulation of adult hippocampal neurogenesis