IMB Seminar Series - Dr Archa Fox - New insights into subnuclear paraspeckles: where long noncoding RNA meets phase separation

Event Details

Date:

Friday, 27 April 2018

Time:

12:30 pm - 1:30 pm

Room:

QBP Auditorium

UQ Location:

Queensland Bioscience Precinct (St Lucia)

URL:

https://imb.uq.edu.au/event/8822/imb-friday-seminar-series

Event category(s):

Full Description:: New insights into subnuclear paraspeckles: where long noncoding RNA meets phase separation.

Paraspeckles are protein-rich nuclear organelles built around a specific long noncoding RNA scaffold. New discoveries show how paraspeckles are formed through multiple RNA-protein and protein-protein interactions, some of which involve multivalent interactions driving phase separation. Once formed, paraspeckles influence gene regulation through sequestration of component proteins and RNAs, with subsequent depletion in other compartments. Here I will focus on the dual aspects of paraspeckle structure and function, revealing an emerging role for these dynamic bodies in a multitude of cellular settings, including, in particular, cancer.