Event Details

Wednesday, 20 September 2017 - Wednesday, 20 September 2017
11:00 am - 12:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
3346 6300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Dr Justin Wong - Head, Gene Regulation in Cancer Lab, Gene and Stem Cell Therapy Program, Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney

Title: 'Intronic nonsense: Why we should stop ignoring them?'

Eukaryotic messenger RNAs (mRNAs) consist of coding regions called exons, separated by non-coding regions called introns. Under normal circumstances, introns are removed by a process called mRNA splicing, which allows joining together of exons to form mature mRNA transcripts, ready for protein translation. Retention of intron is traditionally viewed as a consequence of mis-splicing with little biological relevance. However, we and others have recently shown that intron retention is a widespread and conserved mechanism of gene expression control in normal cells. Aberrant intron retention is also implicated in diverse human disease. In this talk, I will highlight the functions of intron retention in normal biology and disease including those occurring in neuronal cells. I will also discuss my recent work concerning the control of intron retention via MeCP2-mediated splicing factor recruitment consequent to reduced DNA methylation.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

Event Tools

Share This Event

Print this Article Print

Print this Article Email

Share this Article Share

Rate This Event

Tweet This Event

Export This Event

Export calendar

Calendar Tools

Filter by Keywords/Dates

Featured Calendars

Subscribe via RSS