Event Details

Friday, 18 August 2017
12:30 pm - 1:30 pm
Queensland Bioscience Precinct Auditorium - Building 80, The University of Queensland
UQ Location:
Queensland Bioscience Precinct (St Lucia)
Event category(s):

Event Contact

Ms Katrina Garner-Moore
3346 2110
Org. Unit:
Institute for Molecular Bioscience

Event Description

Full Description:
Mitochondrial herniation and mtDNA release during cell death

Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that oligomerise in the mitochondrial outer-membrane to induce permeabilization, leading to cytochrome-c efflux and activation of apoptotic caspases. Recent evidence indicates that, in the absence of active caspases, mitochondrial (mt) DNA triggers the innate immune cGAS/STING pathway, causing dying cells to secrete type I interferon. How cGAS gains access to mtDNA remains unclear, particularly since BAK/BAX are not thought to permeabilize the organelle’s inner membrane. Using live-cell lattice light-sheet, 3D-structured illuminated and immunogold electron microscopy, we have now shown that BAK/BAX activation leads to mitochondrial inner-membrane herniation and release of mtDNA.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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