Event Details

Date:
Friday, 26 May 2017
Time:
12:30 pm - 1:30 pm
Room:
Queensland Bioscience Precinct Auditorium - Building 80, The University of Queensland
UQ Location:
Queensland Bioscience Precinct (St Lucia)
URL:
http://events.imb.uq.edu.au/seminar.php?id=1174
Event category(s):

Event Contact

Name:
Ms Katrina Garner-Moore
Phone:
3346 2110
Email:
k.garnermoore@uq.edu.au
Org. Unit:
Institute for Molecular Bioscience

Event Description

Full Description:
Genome-wide association studies (GWAS) have identified a large number of genetic variants associated with human complex traits. However, genes or functional DNA elements through which these variants exert their effects on the traits are often unknown. I will present a method (called SMR) that integrates summary-level data from GWAS and eQTL studies to identify genes whose expression levels are associated with a trait. An application of the method to large data sets for five complex traits identifies 126 genes, of which 77 genes (~61%) are not the nearest genes of the GWAS top SNPs. I will then show how this method can be extended to include other types of omics data to pinpoint the functional elements where the causal variants are possibly located. The method and results are helpful for the design of follow-up functional studies to understand the genetic basis of complex disease.

Directions to UQ

Google Map:
Directions:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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