Event Details

Friday, 17 February 2017
12:00 pm - 1:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
334 66300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Dr Adam K. Walker
Department of Biomedical Sciences, Faculty of Medicine and Health, Macquarie University, NSW

Title: Investigating the disease mechanisms of MND and frontotemporal dementia related to TDP-43 pathology

Abstract: Motor neuron disease and frontotemporal dementia are devastating neurodegenerative diseases with seemingly disparate symptoms. However, most cases of both diseases are characterized by neuronal pathology containing the DNA/RNA-binding protein TDP-43. In this talk I will present findings from new transgenic TDP-43 mouse models, which recapitulate disease-reminiscent pathology, neurodegeneration and behavioural phenotypes. Importantly, I will show that halting TDP-43 accumulation allows neuron survival and functional recovery even at advanced stages of disease, suggesting that similar strategies could be beneficial in patients. I will also describe recent high-coverage quantitative proteomics studies, which have revealed potential new therapeutic targets for the treatment of TDP-43-associated diseases.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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