QBI Neuroscience Seminar: Translational Neuromodeling

Event Details

Date:

Friday, 07 October 2016

Time:

12:00 pm - 1:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Queensland Brain Institute (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Professor Klaas Enno Stephan
Director,Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Switzerland

Title: Translational Neuromodeling

Abstract: For many brain diseases, particularly in psychiatry, we lack objective diagnostic tests and cannot predict optimal treatment for individual patients. This presentation outlines a translational neuromodeling framework which aims at establishing “computational assays” for inferring subject-specific mechanisms of brain disease from non-invasive measures of behaviour and neuronal activity. Such assays, derived from a generative modelling approach, may provide a formal basis for differential diagnosis and treatment predictions in individual patients and, eventually, facilitate the construction of pathophysiologically grounded disease classifications. The framework presented emphasises the importance of prospective validation studies in patients and of concrete clinical problems for providing benchmarks for model validation. I will show some early (and mostly very simple) proof of concept studies in patients, and outline the opportunities and challenges that lie ahead.