Event Details

Tuesday, 06 September 2016
12:00 pm - 1:00 pm
Large Seminar Room (3.142), Level 3,
UQ Location:
Queensland Bioscience Precinct (St Lucia)
Event category(s):

Event Contact

Miss Hannah Hardy
334 62092
Org. Unit:
Queensland Alliance for Agriculture and Food Innovation

Event Description

Full Description:
Diagnosis of animal diseases has shifted to molecular methods. The reliance on yes or no results from molecular methods can lead to problems. The talk will explore the reason for failures and why it was important to look at the results in a holistic way, rather than only to rely on the PCR results. This holistic approach is also needed for diagnostics that are focused on helping guide vaccine programs and vaccine development. Vaccine development leaving out the diversity of strains and the change in that diversity over time is destined to fail.

The talk will explore some case studies to highlight the problems and the holistic approaches needed to solve them:

In one case scenario the wrong answer by molecular tests was encountered when a PCR gave false negative results. The species in question was Haemophilus parasuis and the species specific PCR test maintained that the found species was not Haemophilus parasuis. The talk will explore the reason for this failure and why it was important to look at the results in a holistic way, rather than only to rely on the PCR results.

The best example for diagnostics geared to help in vaccine programs and vaccine development, is our work on two species of bacteria Pasteurella multocida and Actinobacillus pleuropneumoniae. In the case of P. multocida, it is the lipopolysaccharides that are causing major problems when it comes to diagnostic tests and vaccine protection, while for A. pleuropneumoniae it is the toxin variations that have not been considered and seem to cause some major problems. The talk will look at our molecular approaches to help solve these problems.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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