IMB Seminar Series - Professor Melissa Little - Building organs in dishes: moving from party trick to medical application
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- Seminar Host: Professor Paul Alewood
The concept of regenerative medicine has been with us for some time. However, with the exception of the culture of relatively simple structures, such as skin or cartilage, the bioengineering of complex organs has been a major challenge. Recent advances in the directed differentiation of human pluripotent stem cells is beginning to move this from fiction to reality. The realisation that the differentiation of such cells can result in the formation of organoids comprised of multiple cell types, and that these cell types know how to arrange themselves to begin to recapitulate function, is a major advance in regenerative medicine. Organoids of complex structures, such as the eye, brain, intestine and kidney, have now been described. At first blush, for patients seeking alternatives to current treatment options, this is fantastic news. The actual delivery of a clinical treatment, however, remains in the distance. So what is feasible currently, what is still needed to move this into clinical trial and is this likely? In the interim, what else can we learn from building mini-organs in a dish that may change medical practice?
*SEATING IS LIMITED. Please arrive early to avoid disappointment.*
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